[HTML][HTML] The postnatal GABA shift: a developmental perspective
C Peerboom, CJ Wierenga - Neuroscience & Biobehavioral Reviews, 2021 - Elsevier
GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …
[HTML][HTML] Autism spectrum disorder: focus on glutamatergic neurotransmission
M Montanari, G Martella, P Bonsi… - International Journal of …, 2022 - mdpi.com
Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …
[HTML][HTML] Symptom improvement in children with autism spectrum disorder following bumetanide administration is associated with decreased GABA/glutamate ratios
Bumetanide has been reported to alter synaptic excitation–inhibition (EI) balance by
potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating the severity of …
potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating the severity of …
[HTML][HTML] Perineuronal net degradation rescues CA2 plasticity in a mouse model of Rett syndrome
KE Carstens, DJ Lustberg… - The Journal of …, 2021 - Am Soc Clin Investig
Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the
brains of people with Rett syndrome (RTT). We previously reported that PNNs function to …
brains of people with Rett syndrome (RTT). We previously reported that PNNs function to …
[HTML][HTML] Pharmacological tools to target NKCC1 in brain disorders
The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of
neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated …
neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated …
[HTML][HTML] Shifting developmental trajectories during critical periods of brain formation
N Dehorter, I Del Pino - Frontiers in cellular neuroscience, 2020 - frontiersin.org
Research on critical periods of brain development is greatly expanding our understanding of
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …
Ontogeny of the circadian system: a multiscale process throughout development
The 24 h (circadian) timing system develops in mammals during the perinatal period. It
carries out the essential task of anticipating daily recurring environmental changes to identify …
carries out the essential task of anticipating daily recurring environmental changes to identify …
[HTML][HTML] Machine learning analysis of pregnancy data enables early identification of a subpopulation of newborns with ASD
H Caly, H Rabiei, P Coste-Mazeau, S Hantz, S Alain… - Scientific reports, 2021 - nature.com
To identify newborns at risk of developing ASD and to detect ASD biomarkers early after
birth, we compared retrospectively ultrasound and biological measurements of babies …
birth, we compared retrospectively ultrasound and biological measurements of babies …
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
KJ Peall, MJ Owen, J Hall - Nature Reviews Neurology, 2024 - nature.com
Understanding rare genetic brain disorders with overlapping neurological and psychiatric
phenotypes is of increasing importance given the potential for developing disease models …
phenotypes is of increasing importance given the potential for developing disease models …
[HTML][HTML] Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?
D Pozzi, M Rasile, I Corradini, M Matteoli - Translational psychiatry, 2020 - nature.com
Chloride homeostasis, the main determinant factor for the dynamic tuning of GABAergic
inhibition during development, has emerged as a key element altered in a wide variety of …
inhibition during development, has emerged as a key element altered in a wide variety of …