GABA is the major inhibitory neurotransmitter that counterbalances excitation in the mature
brain. The inhibitory action of GABA relies on the inflow of chloride ions (Cl−), which …

Disturbances in the glutamatergic system have been increasingly documented in several
neuropsychiatric disorders, including autism spectrum disorder (ASD). Glutamate-centered …

Bumetanide has been reported to alter synaptic excitation–inhibition (EI) balance by
potentiating the action of γ-aminobutyric acid (GABA), thereby attenuating the severity of …

Perineuronal nets (PNNs), a specialized form of extracellular matrix, are abnormal in the
brains of people with Rett syndrome (RTT). We previously reported that PNNs function to …

The chloride importer NKCC1 and the chloride exporter KCC2 are key regulators of
neuronal chloride concentration. A defective NKCC1/KCC2 expression ratio is associated …

Research on critical periods of brain development is greatly expanding our understanding of
the cellular and molecular mechanisms underlying the epochs of heightened plasticity …

The 24 h (circadian) timing system develops in mammals during the perinatal period. It
carries out the essential task of anticipating daily recurring environmental changes to identify …

To identify newborns at risk of developing ASD and to detect ASD biomarkers early after
birth, we compared retrospectively ultrasound and biological measurements of babies …

Understanding rare genetic brain disorders with overlapping neurological and psychiatric
phenotypes is of increasing importance given the potential for developing disease models …

Chloride homeostasis, the main determinant factor for the dynamic tuning of GABAergic
inhibition during development, has emerged as a key element altered in a wide variety of …