The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents

M Butnariu, C Quispe, J Herrera-Bravo… - Oxidative medicine …, 2022 - Wiley Online Library
Crocus species are mainly distributed in North Africa, Southern and Central Europe, and
Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus …

Dietary carotenoids in cancer chemoprevention and chemotherapy: A review of emerging evidence

RK Saini, YS Keum, M Daglia… - Pharmacological research, 2020 - Elsevier
In recent years, natural products have reemerged as biotherapeutic options, with several
dietary carotenoids, viz. astaxanthin, fucoxanthin, siphonaxanthin, β-cryptoxanthin, α …

Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma

B Awad, AA Hamza, A Al-Maktoum, S Al-Salam, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

[HTML][HTML] A comprehensive review of the pharmacological potential of Crocus sativus and its bioactive apocarotenoids

SI Bukhari, M Manzoor, MK Dhar - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Crocus sativus is an herbaceous plant that belongs to family Iridaceae. It is commonly
known as saffron and has been used for medicinal purposes since many centuries in India …

Safranal prevents liver cancer through inhibiting oxidative stress and alleviating inflammation

Y Abdalla, A Abdalla, AA Hamza, A Amin - Frontiers in Pharmacology, 2022 - frontiersin.org
Despite all efforts, an effective and safe treatment for liver cancer remains elusive. Natural
products and their derived biomolecules are potential resources to mine for novel anti …

Carotenoids in Cancer Apoptosis—The Road from Bench to Bedside and Back

L Koklesova, A Liskova, M Samec, C Buhrmann… - Cancers, 2020 - mdpi.com
An incidence and mortality of cancer are rapidly growing worldwide, especially due to
heterogeneous character of the disease that is associated with irreversible impairment of …

Crocin inhibits the migration, invasion, and epithelial‐mesenchymal transition of gastric cancer cells via miR‐320/KLF5/HIF‐1α signaling

Y Zhou, Q Xu, J Shang, L Lu… - Journal of cellular …, 2019 - Wiley Online Library
The biological activities of crocin, one of the main bioactive compounds of saffron, include
anti‐inflammatory, antioxidant, antidepressant, and anticancer effects. Crocin has been …

Crocins: A comprehensive review of structural characteristics, pharmacokinetics and therapeutic effects

Y Song, Y Wang, Y Zheng, T Liu, C Zhang - Fitoterapia, 2021 - Elsevier
Crocins, as a kind of water-soluble carotenoid pigment, are a series of ester compounds
formed from crocetin and gentibiose or glucose, and mainly distributed among Crocus …

Dietary crocin is protective in pancreatic cancer while reducing radiation-induced hepatic oxidative damage

HA Bakshi, MSA Zoubi, HL Faruck, AAA Aljabali… - Nutrients, 2020 - mdpi.com
Pancreatic cancer is one of the fatal causes of global cancer-related deaths. Although
surgery and chemotherapy are standard treatment options, post-treatment outcomes often …

Advances on the anti-tumor mechanisms of the carotenoid Crocin

X Bao, J Hu, Y Zhao, R Jia, H Zhang, L Xia - PeerJ, 2023 - peerj.com
Saffron is located in the upper part of the crocus stigma of iridaceae, which has a long
history of medicinal use. Crocin (molecular formula C 44 H 64 O 24) is a natural floral …