Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

The Pseudomonas quinolone signal (PQS) has been studied primarily in the context of its
role as a quorum-sensing signaling molecule. Recent data suggest, however, that this …

The pqs quorum sensing (QS) system is crucial for Pseudomonas aeruginosa virulence both
in vitro and in animal models of infection and is considered an ideal target for the …

Antimicrobial resistance (AMR) is a serious threat to public health globally, manifested by
the frequent emergence of multidrug resistant pathogens that render current chemotherapy …

The Gram-negative opportunistic pathogen Pseudomonas aeruginosa causes severe
nosocomial infections. It uses quorum sensing (QS) to regulate and coordinate population …

Rising numbers of cases of multidrug-and extensively drug-resistant Pseudomonas
aeruginosa over recent years have created an urgent need for novel therapeutic …

Nowadays, due to spreading antibiotic resistance among clinically relevant pathogens, the
requirement of novel therapeutic approaches is felt more than ever. One of the alternative …

Faced with the global health threat of increasing resistance to antibiotics, researchers are
exploring interventions that target bacterial virulence factors. Quorum sensing is a …

Type III polyketide synthases (PKSs) produce an incredibly diverse group of plant
specialized metabolites with medical importance despite their structural simplicity compared …

The 4-quinolones and their analogs are a heterogeneous group of biologically active
compounds that have evolved in modern days to provide utilities at the forefront of antibiotic …