In this review study, we aimed to introduce the orexinergic system as an important signaling
pathway involved in a variety of cognitive functions such as memory, motivation, and reward …

Relaxin‐3 has been proposed to modulate emotional–behavioural functions such as
arousal and behavioural activation, appetite regulation, stress responses, anxiety, memory …

There is much interest in identifying novel pharmacotherapeutic targets that improve clinical
outcomes for the treatment of alcohol use disorder (AUD). One promising target for …

Key points Relaxin‐3 is a stress‐responsive neuropeptide that acts at its cognate receptor,
RXFP3, to alter behaviours including feeding. In this study, we have demonstrated a direct …

Binge eating is frequently stimulated by stress. The neuropeptide relaxin-3 (RLN3) and its
native receptor RXFP3 are implicated in stress and appetitive behaviors. We investigated …

Binge-eating disorder is the most common eating disorder. Various neuropeptides play
important roles in the regulation of feeding behavior, including relaxin-3 (RLN3), which …

Many physiological processes fluctuate throughout the day/night and daily fluctuations are
observed in brain and peripheral levels of several hormones, neuropeptides and …

Hippocampus is innervated by γ‐aminobutyric acid (GABA)“projection” neurons of the
nucleus incertus (NI), including a population expressing the neuropeptide, relaxin‐3 (RLN3) …

In male heterogametic systems, the X Chromosome is epigenetically differentiated between
males and females, to facilitate dosage compensation. For example, the X Chromosome in …

Abstract The neuropeptide relaxin-3 (RLN3) binds with high affinity to its cognate receptor,
relaxin-family peptide receptor 3 (RXFP3), and with lower affinity to RXFP1, the cognate …