The physiology of glucagon-like peptide 1

JJ Holst - Physiological reviews, 2007 - journals.physiology.org
Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the
intestinal epithelial endocrine L-cells by differential processing of proglucagon, the gene …

The role of incretins in glucose homeostasis and diabetes treatment

W Kim, JM Egan - Pharmacological reviews, 2008 - ASPET
Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

Cardioprotective and vasodilatory actions of glucagon-like peptide 1 receptor are mediated through both glucagon-like peptide 1 receptor–dependent and …

K Ban, MH Noyan-Ashraf, J Hoefer, SS Bolz… - Circulation, 2008 - Am Heart Assoc
Background—The glucagon-like peptide 1 receptor (GLP-1R) is believed to mediate
glucoregulatory and cardiovascular effects of the incretin hormone GLP-1 (7-36)(GLP-1) …

The glucagon-like peptides

TJ Kieffer, J Francis Habener - Endocrine reviews, 1999 - academic.oup.com
Glucagon-Like Peptides | Endocrine Reviews | Oxford Academic Skip to Main Content
Advertisement Oxford Academic Journals Books Search Menu Information Account Menu …

Mechanisms of action of glucagon-like peptide 1 in the pancreas

ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - Elsevier
Glucagon-like peptide 1 (GLP-1) is a hormone that is encoded in the proglucagon gene. It is
mainly produced in enteroendocrine L cells of the gut and is secreted into the blood stream …

GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic Male ApoE−/− Mice

N Panjwani, EE Mulvihill, C Longuet, B Yusta… - …, 2013 - academic.oup.com
Glucagon-like peptide-1 receptor (GLP-1R) agonists reduce lipid accumulation in peripheral
tissues, attenuating atherosclerosis and hepatic steatosis in preclinical studies. We …

[HTML][HTML] The role of gut hormones in glucose homeostasis

DJ Drucker - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
The gastrointestinal tract has a crucial role in the control of energy homeostasis through its
role in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals …

Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans

JJ Holst, J Gromada - American Journal of Physiology …, 2004 - journals.physiology.org
The available evidence suggests that about two-thirds of the insulin response to an oral
glucose load is due to the potentiating effect of gut-derived incretin hormones. The strongest …

The origin and function of the pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily

NM Sherwood, SL Krueckl, JE McRory - Endocrine reviews, 2000 - academic.oup.com
The pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
includes nine hormones in humans that are related by structure, distribution (especially the …

Improvement of glucose tolerance and hepatic insulin sensitivity by oligofructose requires a functional glucagon-like peptide 1 receptor

PD Cani, C Knauf, MA Iglesias, DJ Drucker… - Diabetes, 2006 - Am Diabetes Assoc
Nondigestible fermentable dietary fibers such as oligofructose (OFS) exert an antidiabetic
effect and increase the secretion of glucagon-like peptide 1 (GLP-1). To determine the …