The Ras-dependent extracellular signal-regulated kinase (ERK) 1/2 mitogen-activated
protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells …

The Ras/Raf/MEK/ERK signaling cascade that integrates an extreme variety of extracellular
stimuli into key biological responses controlling cell proliferation, differentiation or death is …

The roles of the JAK/STAT, Raf/MEK/ERK and PI3K/Akt signal transduction pathways and
the BCR-ABL oncoprotein in leukemogenesis and their importance in the regulation of cell …

The mitogen-activated protein kinase (MAPK) superfamily consists of three main protein
kinase families: the extracellular signal-regulated protein kinases (ERKs), the c-Jun N …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Signaling between tissues is essential to form the complex, three-dimensional organization
of an embryo. Because many receptor tyrosine kinases signal through the RAS-MAPK …

Isothiocyanate sulforaphane is an extensively studied cancer chemopreventive agent in
human diet. In this study, the effects of sulforaphane (SFN) and its sulfide analog, erucin …

Stress granules aid cell survival in response to environmental stressors by acting as sites of
translational repression. We report an unanticipated link between stress granules and the …

The mitogen-activated protein kinase (MAPK) family of kinases connects extracellular stimuli
with diverse cellular responses ranging from activation or suppression of gene expression to …

At late mitosis, the mother cell divides by the formation of a cleavage furrow, leaving two
daughter cells connected by a thin intercellular bridge. During ingression of the cleavage …