The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …

Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …

Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …

The klotho gene, named after a Greek goddess who spins the thread of life, was identified as
a putative 'ageing-suppressor'gene. Klotho-deficient mice exhibit complex ageing-like …

The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …

Many of the> 2 million animal species that inhabit Earth have developed survival
mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration …

Objective We systematically review the literature on social epigenetics, examining how
empirical research to date has conceptualized and operationalized social determinants of …

The sum total of life course exposures creates an exposome that has a significant impact on
age-related health. Understanding the interplay between exposome factors and the (epi) …

Red meat is an important dietary source of high biological value protein and micronutrients
such as vitamins, iron, and zinc that exert many beneficial functions. However, high …

An ability to separate natural ageing processes from processes specific to morbidities is
required to understand the heterogeneity of age-related organ dysfunction. Mechanistic …