Food as medicine: targeting the uraemic phenotype in chronic kidney disease
D Mafra, NA Borges, B Lindholm, PG Shiels… - Nature Reviews …, 2021 - nature.com
The observation that unhealthy diets (those that are low in whole grains, fruits and
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …
vegetables, and high in sugar, salt, saturated fat and ultra-processed foods) are a major risk …
Klotho, aging, and the failing kidney
S Buchanan, E Combet, P Stenvinkel… - Frontiers in …, 2020 - frontiersin.org
Klotho has been recognized as a gene involved in the aging process in mammals for over
30 years, where it regulates phosphate homeostasis and the activity of members of the …
30 years, where it regulates phosphate homeostasis and the activity of members of the …
Inflammation and premature ageing in chronic kidney disease
T Ebert, SC Pawelzik, A Witasp, S Arefin, S Hobson… - Toxins, 2020 - mdpi.com
Persistent low-grade inflammation and premature ageing are hallmarks of the uremic
phenotype and contribute to impaired health status, reduced quality of life, and premature …
phenotype and contribute to impaired health status, reduced quality of life, and premature …
Klotho and calciprotein particles as therapeutic targets against accelerated ageing
M Kuro-o - Clinical Science, 2021 - portlandpress.com
The klotho gene, named after a Greek goddess who spins the thread of life, was identified as
a putative 'ageing-suppressor'gene. Klotho-deficient mice exhibit complex ageing-like …
a putative 'ageing-suppressor'gene. Klotho-deficient mice exhibit complex ageing-like …
Accelerated vascular aging in chronic kidney disease: the potential for novel therapies
S Hobson, S Arefin, A Witasp, L Hernandez… - Circulation …, 2023 - Am Heart Assoc
The pathophysiology of vascular disease is linked to accelerated biological aging and a
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …
combination of genetic, lifestyle, biological, and environmental risk factors. Within the …
Novel treatment strategies for chronic kidney disease: insights from the animal kingdom
Many of the> 2 million animal species that inhabit Earth have developed survival
mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration …
mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration …
How are social determinants of health integrated into epigenetic research? A systematic review
Objective We systematically review the literature on social epigenetics, examining how
empirical research to date has conceptualized and operationalized social determinants of …
empirical research to date has conceptualized and operationalized social determinants of …
Manipulating the exposome to enable better ageing
PG Shiels, J Painer, B Natterson-Horowitz… - Biochemical …, 2021 - portlandpress.com
The sum total of life course exposures creates an exposome that has a significant impact on
age-related health. Understanding the interplay between exposome factors and the (epi) …
age-related health. Understanding the interplay between exposome factors and the (epi) …
Red meat intake in chronic kidney disease patients: Two sides of the coin
D Mafra, NA Borges, LFM de Franca Cardozo, JS Anjos… - Nutrition, 2018 - Elsevier
Red meat is an important dietary source of high biological value protein and micronutrients
such as vitamins, iron, and zinc that exert many beneficial functions. However, high …
such as vitamins, iron, and zinc that exert many beneficial functions. However, high …
The role of epigenetics in renal ageing
PG Shiels, D McGuinness, M Eriksson… - Nature Reviews …, 2017 - nature.com
An ability to separate natural ageing processes from processes specific to morbidities is
required to understand the heterogeneity of age-related organ dysfunction. Mechanistic …
required to understand the heterogeneity of age-related organ dysfunction. Mechanistic …