High-throughput methods in the discovery and study of biomaterials and materiobiology
The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …
pivotal role in the development of novel implants, biomedical devices, and tissue …
[HTML][HTML] Cells as active particles in asymmetric potentials: motility under external gradients
Cell migration is a crucial event during development and in disease. Mechanical constraints
and chemical gradients can contribute to the establishment of cell direction, but their …
and chemical gradients can contribute to the establishment of cell direction, but their …
Nanopatterns of surface-bound ephrinB1 produce multivalent ligand–receptor interactions that tune EphB2 receptor clustering
V Hortigüela, E Larrañaga, F Cutrale, A Seriola… - Nano …, 2018 - ACS Publications
Here we present a nanostructured surface able to produce multivalent interactions between
surface-bound ephrinB1 ligands and membrane EphB2 receptors. We created ephrinB1 …
surface-bound ephrinB1 ligands and membrane EphB2 receptors. We created ephrinB1 …
Engineering spatial gradients of signaling proteins using magnetic nanoparticles
L Bonnemay, S Hostachy, C Hoffmann, J Gautier… - Nano …, 2013 - ACS Publications
Intracellular biochemical reactions are often localized in space and time, inducing gradients
of enzymatic activity that may play decisive roles in determining cell's fate and functions …
of enzymatic activity that may play decisive roles in determining cell's fate and functions …
High-throughput cell motility studies on surface-bound protein nanoparticles with diverse structural and compositional characteristics
WI Tatkiewicz, J Seras-Franzoso… - ACS biomaterials …, 2019 - ACS Publications
Eighty areas with different structural and compositional characteristics made of bacterial
inclusion bodies formed by the fibroblast growth factor (FGF-IBs) were simultaneously …
inclusion bodies formed by the fibroblast growth factor (FGF-IBs) were simultaneously …
Direct micrometer patterning and functionalization of polymer blend surfaces by using hot embossing
M Palacios-Cuesta, I Vasiev, N Gadegaard… - European polymer …, 2014 - Elsevier
Micrometer and submicrometer size features were prepared in poly (methyl methacrylate)
based polymer blends by hot-embossing using a customized silicon master. The surface …
based polymer blends by hot-embossing using a customized silicon master. The surface …
Method and device for generating a tunable array of fluid gradients
MD Estes, CM Hurth, F Zenhausern - US Patent 9,409,173, 2016 - Google Patents
Provided herein are devices and methods for generating microfluidic gradients, including an
array of unique microfluidic gradients within an array of microchannels. Fluids within …
array of unique microfluidic gradients within an array of microchannels. Fluids within …
[HTML][HTML] Microstructured polymer blend surfaces produced by spraying functional copolymers and their blends
N Vargas-Alfredo, J Rodríguez Hernández - Materials, 2016 - mdpi.com
We described the fabrication of functional and microstructured surfaces from polymer blends
by spray deposition. This simple technique offers the possibility to simultaneously finely tune …
by spray deposition. This simple technique offers the possibility to simultaneously finely tune …
How to Get Away with Gradients
J Comelles, Ó Castillo-Fernández… - … and Biosensors in Cancer …, 2022 - Springer
Biomolecular gradients are widely present in multiple biological processes. Historically they
were reproduced in vitro by using micropipettes, Boyden and Zigmond chambers, or …
were reproduced in vitro by using micropipettes, Boyden and Zigmond chambers, or …
Influence of Controlled Micro‐and Nanoengineered Environments on Stem Cell Fate
A Lagunas, A Lagunas, D Caballero… - … Surfaces for Stem …, 2016 - Wiley Online Library
The development of micro-and nanotechnologies has allowed the fabrication of novel
engineered environments for the study of cell–surface interaction at the micro-and …
engineered environments for the study of cell–surface interaction at the micro-and …