The complex interaction of cells with biomaterials (ie, materiobiology) plays an increasingly
pivotal role in the development of novel implants, biomedical devices, and tissue …

Cell migration is a crucial event during development and in disease. Mechanical constraints
and chemical gradients can contribute to the establishment of cell direction, but their …

Here we present a nanostructured surface able to produce multivalent interactions between
surface-bound ephrinB1 ligands and membrane EphB2 receptors. We created ephrinB1 …

Intracellular biochemical reactions are often localized in space and time, inducing gradients
of enzymatic activity that may play decisive roles in determining cell's fate and functions …

Eighty areas with different structural and compositional characteristics made of bacterial
inclusion bodies formed by the fibroblast growth factor (FGF-IBs) were simultaneously …

Micrometer and submicrometer size features were prepared in poly (methyl methacrylate)
based polymer blends by hot-embossing using a customized silicon master. The surface …

Provided herein are devices and methods for generating microfluidic gradients, including an
array of unique microfluidic gradients within an array of microchannels. Fluids within …

We described the fabrication of functional and microstructured surfaces from polymer blends
by spray deposition. This simple technique offers the possibility to simultaneously finely tune …

Biomolecular gradients are widely present in multiple biological processes. Historically they
were reproduced in vitro by using micropipettes, Boyden and Zigmond chambers, or …

The development of micro-and nanotechnologies has allowed the fabrication of novel
engineered environments for the study of cell–surface interaction at the micro-and …