Targeted covalent inhibitors (TCIs) are designed to bind poorly conserved amino acids by
means of reactive groups, the so-called warheads. Currently, targeting noncatalytic cysteine …

Advances in bioconjugation and native protein modification are appearing at a blistering
pace, making it increasingly time consuming for practitioners to identify the best chemical …

Tissue adhesives have garnered extensive interest as alternatives and supplements to
sutures, whereas major challenges still remain, including weak tissue adhesion, inadequate …

Recent advances in chemical proteomics have begun to characterize the reactivity and
ligandability of lysines on a global scale. Yet, only a limited diversity of aminophilic …

Injectable antibacterial hydrogels have attracted considerable attention in wound
management. However, the development of injectable hydrogels with excellent antibacterial …

Proteins are multifunctional large organic compounds that constitute an essential
component of a living system. Hence, control over their bioconjugation impacts science at …

Cyclic peptides are drawing wide attention as potential medium-sized modulators of
biomolecular interactions with large binding surfaces. Simple but effective peptide …

Despite recent interests in developing lysine‐targeting covalent inhibitors, no general
approach is available to create such compounds. We report herein a general approach to …

Chemical cross-linking of proteins coupled with mass spectrometry is widely used in protein
structural analysis. In this study we develop a class of non-hydrolyzable amine-selective di …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …