Modeling neoplastic disease with spheroids and organoids
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …
components contribute to the development, progression, and metastasization of disease …
Zebrafish patient avatars in cancer biology and precision cancer therapy
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
relevant tumour behaviours, such as treatment response and emergence of drug resistance …
Zebrafish as a model system to study toxicology
YJ Dai, YF Jia, N Chen, WP Bian, QK Li… - Environmental …, 2014 - Wiley Online Library
Monitoring and assessing the effects of contaminants in the aquatic eco‐environment is
critical in protecting human health and the environment. The zebrafish has been widely used …
critical in protecting human health and the environment. The zebrafish has been widely used …
Application of animal models in cancer research: recent progress and future prospects
Z Li, W Zheng, H Wang, Y Cheng, Y Fang… - Cancer management …, 2021 - Taylor & Francis
Animal models refers to the animal experimental objects and related materials that can
simulate human body established in medical research. As the second-largest disease in …
simulate human body established in medical research. As the second-largest disease in …
Microfluidics: a new tool for modeling cancer–immune interactions
In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …
Patient-derived glioma models: from patients to dish to animals
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …
associated with a poor survival. Current standard of care consists of surgical resection …
Zebrafish as a preclinical in vivo screening model for nanomedicines
S Sieber, P Grossen, J Bussmann, F Campbell… - Advanced drug delivery …, 2019 - Elsevier
The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …
their physicochemical properties. Formulation design and optimization are therefore key …
From seeing to believing: labelling strategies for in vivo cell-tracking experiments
F Progatzky, MJ Dallman, C Lo Celso - Interface focus, 2013 - royalsocietypublishing.org
Intravital microscopy has become increasingly popular over the past few decades because it
provides high-resolution and real-time information about complex biological processes …
provides high-resolution and real-time information about complex biological processes …
Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era
CJ Veinotte, G Dellaire… - Disease models & …, 2014 - journals.biologists.com
The current preclinical pipeline for drug discovery can be cumbersome and costly, which
limits the number of compounds that can effectively be transitioned to use as therapies …
limits the number of compounds that can effectively be transitioned to use as therapies …
Benefits of zebrafish xenograft models in cancer research
X Chen, Y Li, T Yao, R Jia - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …