Modeling neoplastic disease with spheroids and organoids

M Zanoni, M Cortesi, A Zamagni, C Arienti… - Journal of hematology & …, 2020 - Springer
Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Zebrafish patient avatars in cancer biology and precision cancer therapy

M Fazio, J Ablain, Y Chuan, DM Langenau… - Nature Reviews …, 2020 - nature.com
In precision oncology, two major strategies are being pursued for predicting clinically
relevant tumour behaviours, such as treatment response and emergence of drug resistance …

Zebrafish as a model system to study toxicology

YJ Dai, YF Jia, N Chen, WP Bian, QK Li… - Environmental …, 2014 - Wiley Online Library
Monitoring and assessing the effects of contaminants in the aquatic eco‐environment is
critical in protecting human health and the environment. The zebrafish has been widely used …

Application of animal models in cancer research: recent progress and future prospects

Z Li, W Zheng, H Wang, Y Cheng, Y Fang… - Cancer management …, 2021 - Taylor & Francis
Animal models refers to the animal experimental objects and related materials that can
simulate human body established in medical research. As the second-largest disease in …

Microfluidics: a new tool for modeling cancer–immune interactions

A Boussommier-Calleja, R Li, MB Chen, SC Wong… - Trends in cancer, 2016 - cell.com
In recognition of the enormous potential of immunotherapies against cancer, research into
the interactions between tumor and immune cells has accelerated, leading to the recent FDA …

Patient-derived glioma models: from patients to dish to animals

CC da Hora, MW Schweiger, T Wurdinger, BA Tannous - Cells, 2019 - mdpi.com
Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults
associated with a poor survival. Current standard of care consists of surgical resection …

Zebrafish as a preclinical in vivo screening model for nanomedicines

S Sieber, P Grossen, J Bussmann, F Campbell… - Advanced drug delivery …, 2019 - Elsevier
The interactions of nanomedicines with biological environments is heavily influenced by
their physicochemical properties. Formulation design and optimization are therefore key …

From seeing to believing: labelling strategies for in vivo cell-tracking experiments

F Progatzky, MJ Dallman, C Lo Celso - Interface focus, 2013 - royalsocietypublishing.org
Intravital microscopy has become increasingly popular over the past few decades because it
provides high-resolution and real-time information about complex biological processes …

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

CJ Veinotte, G Dellaire… - Disease models & …, 2014 - journals.biologists.com
The current preclinical pipeline for drug discovery can be cumbersome and costly, which
limits the number of compounds that can effectively be transitioned to use as therapies …

Benefits of zebrafish xenograft models in cancer research

X Chen, Y Li, T Yao, R Jia - Frontiers in Cell and Developmental …, 2021 - frontiersin.org
As a promising in vivo tool for cancer research, zebrafish have been widely applied in
various tumor studies. The zebrafish xenograft model is a low-cost, high-throughput tool for …