Pathways to neuronal injury and apoptosis in HIV-associated dementia
Abstract Human immunodeficiency virus-1 (HIV-1) can induce dementia with alarming
occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of …
occurrence worldwide. The mechanism remains poorly understood, but discovery in brain of …
Oxidative stress and the pathogenesis of neurodegenerative disorders
A Reynolds, C Laurie, RL Mosley… - International review of …, 2007 - Elsevier
Microglia‐derived inflammatory neurotoxins play a principal role in the pathogenesis of
neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …
neurodegenerative disorders including Alzheimer's disease, Parkinson's disease …
HIV-1 infection and AIDS: consequences for the central nervous system
Infection with the human immunodeficiency virus-1 (HIV-1) can induce severe and
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …
debilitating neurological problems that include behavioral abnormalities, motor dysfunction …
Cells of the central nervous system as targets and reservoirs of the human immunodeficiency virus
S Kramer-Hämmerle, I Rothenaigner, H Wolff, JE Bell… - Virus research, 2005 - Elsevier
The availability of highly active antiretroviral therapies (HAART) has not eliminated HIV-1
infection of the central nervous system (CNS) or the occurrence of HIV-associated …
infection of the central nervous system (CNS) or the occurrence of HIV-associated …
The importance of monocytes and macrophages in HIV pathogenesis, treatment, and cure
JH Campbell, AC Hearps, GE Martin, KC Williams… - Aids, 2014 - journals.lww.com
Monocytes and macrophages play critical roles in HIV transmission, viral spread early in
infection, and as a reservoir of virus throughout infection. There has been a recent …
infection, and as a reservoir of virus throughout infection. There has been a recent …
Mechanisms of neuronal injury and death in HIV-1 associated dementia
Infection with the human immunodeficiency virus-1 (HIV-1) and acquired immunodeficiency
syndrome (AIDS) remain a persistent and even growing health problem worldwide. Besides …
syndrome (AIDS) remain a persistent and even growing health problem worldwide. Besides …
Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants
V Mollace, HSLM Nottet, P Clayette, MC Turco… - Trends in …, 2001 - cell.com
Neurological disorders represent one of the most common disturbances accompanying HIV
infection. In the past few years, highly antiretroviral active therapy has significantly reduced …
infection. In the past few years, highly antiretroviral active therapy has significantly reduced …
HIV‐1 Tat and opiate‐induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP‐1 and alternative chemokines
N El‐Hage, G Wu, J Wang, J Ambati, PE Knapp… - Glia, 2006 - Wiley Online Library
Opiates exacerbate human immunodeficiency virus type 1 (HIV‐1) Tat1‐72‐induced release
of key proinflammatory cytokines by astrocytes, which may accelerate HIV …
of key proinflammatory cytokines by astrocytes, which may accelerate HIV …
TNF-α mediates SDF-1α–induced NF-κB activation and cytotoxic effects in primary astrocytes
Y Han, T He, DR Huang, CA Pardo… - The Journal of …, 2001 - Am Soc Clin Investig
Stromal-derived cell factor-1α (SDF-1α; CXCL12) and its receptor, CXCR4, are constitutively
expressed on neuroepithelial cells and are believed to be involved in both development and …
expressed on neuroepithelial cells and are believed to be involved in both development and …
HIV‐Associated Neurotoxicity: The Interplay of Host and Viral Proteins
HIV‐1 can incite activation of chemokine receptors, inflammatory mediators, and glutamate
receptor‐mediated excitotoxicity. The mechanisms associated with such immune activation …
receptor‐mediated excitotoxicity. The mechanisms associated with such immune activation …