Mounting evidence indicates that inflammatory cytokines contribute to the development of
depression in both medically ill and medically healthy individuals. Cytokines are important …

This work was supported by National Institute of Health (NIH) grants MH-541380, MH-
77083, MH-69056, MH-58922, MH-42088, MH071537, and DA-019624; the Doris Duke …

Multiple sources of evidence support a role for diminished dopaminergic neurotrans-mission
in major depression. The physiological alterations underlying reduced dopa-mine (DA) …

There is abundant evidence for abnormalities of the norepinephrine (NE) and serotonin
(5HT) neurotransmitter systems in depression and anxiety disorders. The majority of …

The classical biogenic amine neurotransmitters—dopamine, noradrenaline, and 5-
hydroxytryptamine—control a variety of functions including locomotion, autonomic function …

Major depressive disorder is a serious medical illness which is responsible for considerable
morbidity and disability. Despite decades of research, the neural basis for depression is still …

Depression describes both a transient mood state experienced by virtually all individuals at
some time in their life as well as a clinical or biobehavioral syndrome, usually called Major …

Major depression is a serious disorder of enormous sociological and clinical relevance. The
discovery of antidepressant drugs in the 1950s led to the first biochemical hypothesis of …

In this study, measures of the quality and availability of social supports were found to
moderate risk for depression associated with a history of maltreatment and the presence of …

Background: The serotonin-1A (5HT1A) receptor system has been implicated in the
pathophysiology of major depression by postmortem studies of suicide victims and …