The transcription factor NF-κB is a critical regulator of immune and inflammatory responses.
In mammals, the NF-κB/Rel family comprises five members: p50, p52, p65 (Rel-A), c-Rel …

Background Exposure to cigarette smoke (CS) is a major threat to human health worldwide.
It is well established that smoking increases the risk of respiratory diseases, cardiovascular …

Environmental chemicals such as bisphenol A (BPA) are thought to contribute to
carcinogenesis through their endocrine-disrupting properties. Due to accumulating evidence …

Epigenetics of asthma and allergic disease is a field that has expanded greatly in the last
decade. Previously thought only in terms of cell differentiation, it is now evident the …

Abstract Background and Aims: Lung cancer is the leading cause of cancer death
worldwide. Cigarette smoking is the well‐known risk factor for lung cancer. Epidemiological …

Highlights•HDAC 3 plays a key role in NF-κB-mediated signaling.•HDAC inhibitors
demonstrate promising anti-inflammatory effects.•Selective HDAC 3 inhibitors have potential …

Histone deacetylases (HDACs) are critical regulators of inflammatory gene expression, and
the efficacy of pan-HDAC inhibitors has been implicated in various disease conditions …

The rapid and persistent increase of drug-resistant Mycobacterium tuberculosis (Mtb)
infections poses increasing global problems in combatting tuberculosis (TB), prompting for …

Histone deacetylases (HDACs) are a superfamily of enzymes that catalyze the removal of
acetyl functional groups from lysine residues of histone and non-histone proteins. There are …

Scope Hypothalamic astrogliosis and inflammation cause neural injury, playing a critical role
in metabolic syndrome development. This study investigated whether and how fructose …