The biochemistry and medical significance of the flavonoids

BH Havsteen - Pharmacology & therapeutics, 2002 - Elsevier
Flavonoids are plant pigments that are synthesised from phenylalanine, generally display
marvelous colors known from flower petals, mostly emit brilliant fluorescence when they are …

Review of the biology of quercetin and related bioflavonoids

JV Formica, W Regelson - Food and chemical toxicology, 1995 - Elsevier
The French paradox is a dietary anomaly which has focused attention on the Mediterranean
diet. Epidemiological studies revealed that this diet, replete in flavonoid-rich foods (Allium …

The impact of plant flavonoids on mammalian biology: implications for immunity, inflammation and cancer

M Elliott, K Chithan - The flavonoids advances in research …, 2017 - api.taylorfrancis.com
15.4 Effects of flavonoids on smooth muscle 15.5 Antitoxic and hepatoprotective effects of
Oavonoids 15.6 Effects of flavonoids on other cells 15.7 Antiviral effects of flavonoids 15.8 …

Cellular responses to Cisplatin‐induced DNA damage

A Basu, S Krishnamurthy - Journal of nucleic acids, 2010 - Wiley Online Library
Cisplatin is one of the most effective anticancer agents widely used in the treatment of solid
tumors. It is generally considered as a cytotoxic drug which kills cancer cells by damaging …

Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition.

DR Ferry, A Smith, J Malkhandi, DW Fyfe… - Clinical cancer research …, 1996 - AACR
We have performed a Phase I clinical trial with the naturally occurring flavonoid quercetin (3,
3', 4', 5, 7-pentahydroxyflavone). Quercetin has antiproliferative activity in vitro and is known …

Dietary antioxidants during cancer chemotherapy: impact on chemotherapeutic effectiveness and development of side effects

KA Conklin - Nutrition and cancer, 2000 - Taylor & Francis
Several studies suggest that dietary supplementation with antioxidants can influence the
response to chemotherapy as well as the development of adverse side effects that results …

Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin

JA Choi, JY Kim, JY Lee, CM Kang… - International …, 2001 - spandidos-publications.com
Quercetin, a widely distributed bioflavonoid, has been shown to induce growth inhibition in
certain cancer cell types. In the present study we have pursued the mechanism of growth …

Vasodilatory effects of flavonoids in rat aortic smooth muscle. Structure-activity relationships.

J Duarte, P Utrilla, J Jimenez, J Tamargo… - General …, 1993 - europepmc.org
1. Flavonoids relaxed the contractions induced by noradrenaline, KCl or phorbol 12-
myristate, 13-acetate in rat aortic strips, the order of potency being: flavonols (quercetin …

The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells

TTT Nguyen, E Tran, TH Nguyen, PT Do… - …, 2004 - academic.oup.com
Dietary phytochemicals have been shown to be protective against various types of cancers.
However, the precise underlying protective mechanisms are poorly understood. In the …

Senile hair graying: H2O2‐mediated oxidative stress affects human hair color by blunting methionine sulfoxide repair

JM Wood, H Decker, H Hartmann, B Chavan… - The FASEB …, 2009 - Wiley Online Library
Senile graying of human hair has been the subject of intense research since ancient times.
Reactive oxygen species have been implicated in hair follicle melanocyte apoptosis and …