We are witnessing a revolution in our understanding of primary aldosteronism (PA). In the
past 2 decades, we have learned that PA is a highly prevalent syndrome that is largely …

Early diagnosis and appropriate treatment of primary aldosteronism, the most frequent
cause of secondary hypertension, are crucial to prevent deleterious cardiovascular …

BACKGROUND. Adrenal aldosterone excess is the most common cause of secondary
hypertension and is associated with increased cardiovascular morbidity. However, adverse …

Somatic mutations have been identified in aldosterone-producing adenomas (APAs) in
genes that include KCNJ5, ATP1A1, ATP2B3, and CACNA1D. Based on independent …

Primary aldosteronism is considered the commonest cause of secondary hypertension. In
affected individuals, aldosterone is produced in an at least partially autonomous fashion in …

Aldosterone and cortisol, the main mineralocorticoid and glucocorticoid hormones in
humans, are produced in the adrenal cortex, which is composed of three concentric zones …

Adrenal cortex produces glucocorticoids, mineralocorticoids and adrenal androgens which
are essential for life, supporting balance, immune response and sexual maturation …

Aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia are the main
cause of primary aldosteronism (PA), the most frequent form of secondary hypertension …

Recent genetic examinations and multisteroid profiles have provided the basis for
subclassification of aldosterone-producing adenomas (APAs). The objective of the current …

Aldosterone‐and cortisol‐coproducing adrenal adenoma (A/CPA) cases have been
observed in patients with primary aldosteronism (PA). This study investigated the incidence …