Spike-heparan sulfate interactions in SARS-CoV-2 infection

FL Kearns, DR Sandoval, L Casalino… - Current opinion in …, 2022 - Elsevier
Recent biochemical, biophysical, and genetic studies have shown that heparan sulfate, a
major component of the cellular glycocalyx, participates in infection of SARS-CoV-2 by …

The role of dendritic cells in COVID-19 infection

X Wang, F Guan, H Miller, MG Byazrova… - Emerging Microbes & …, 2023 - Taylor & Francis
The persistent pandemic of coronavirus disease in 2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently poses a major infectious …

GlycoGrip: Cell Surface-Inspired Universal Sensor for Betacoronaviruses

SH Kim, FL Kearns, MA Rosenfeld, L Casalino… - ACS central …, 2021 - ACS Publications
Inspired by the role of cell-surface glycoproteins as coreceptors for pathogens, we report the
development of GlycoGrip: a glycopolymer-based lateral flow assay for detecting SARS-CoV …

TRIM7 ubiquitinates SARS-CoV-2 membrane protein to limit apoptosis and viral replication

M Gonzalez-Orozco, H Tseng, A Hage, H Xia… - Nature …, 2024 - nature.com
SARS-CoV-2 is a highly transmissible virus that causes COVID-19 disease. Mechanisms of
viral pathogenesis include excessive inflammation and viral-induced cell death, resulting in …

SARS-CoV-2 suppresses TLR4-induced immunity by dendritic cells via C-type lectin receptor DC-SIGN

LEH van der Donk, M Bermejo-Jambrina… - PLoS …, 2023 - journals.plos.org
SARS-CoV-2 causes COVID-19, an infectious disease with symptoms ranging from a mild
cold to severe pneumonia, inflammation, and even death. Although strong inflammatory …

Coreceptor functions of cell surface heparan sulfate proteoglycans

K Hayashida, RS Aquino… - American Journal of …, 2022 - journals.physiology.org
Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …

Antiviral strategies using natural source-derived sulfated polysaccharides in the light of the COVID-19 pandemic and major human pathogenic viruses

B Ray, I Ali, S Jana, S Mukherjee, S Pal, S Ray… - Viruses, 2021 - mdpi.com
Only a mere fraction of the huge variety of human pathogenic viruses can be targeted by the
currently available spectrum of antiviral drugs. The severe acute respiratory syndrome …

Surface charge changes in spike RBD mutations of SARS-CoV-2 and its variant strains alter the virus evasiveness via HSPGs: A review and mechanistic hypothesis

Z Zhang, J Zhang, J Wang - Frontiers in Public Health, 2022 - frontiersin.org
With the COVID-19 pandemic continuing, more contagious SARS-CoV-2 variants, including
Omicron, have been emerging. The mutations, especially those that occurred on the spike …

Current concepts on Pseudomonas aeruginosa interaction with human airway epithelium

A Muggeo, C Coraux, T Guillard - PLoS pathogens, 2023 - journals.plos.org
Pseudomonas aeruginosa is a major, but opportunistic, respiratory pathogen, which rarely
infects healthy individuals, mainly due to the barrier effect of the human airway epithelium …

Seaweed-derived fucoidans and rhamnan sulfates serve as potent anti-SARS-CoV-2 agents with potential for prophylaxis

Y Song, A Singh, MM Feroz, S Xu, F Zhang, W Jin… - Carbohydrate …, 2024 - Elsevier
Seaweeds represent a rich source of sulfated polysaccharides with similarity to heparan
sulfate, a facilitator of myriad virus host cell attachment. For this reason, attention has been …