Bioengineered cellular and cell membrane-derived vehicles for actively targeted drug delivery: so near and yet so far

MY Thanuja, C Anupama, SH Ranganath - Advanced drug delivery reviews, 2018 - Elsevier
Cellular carriers for drug delivery are attractive alternatives to synthetic nanoparticles owing
to their innate homing/targeting abilities. Here, we review molecular interactions involved in …

Galectin-3 and cancer stemness

P Nangia-Makker, V Hogan, A Raz - Glycobiology, 2018 - academic.oup.com
Over the last few decades galectin-3, a carbohydrate binding protein, with affinity for N-
acetyllactosamine residues, has been unique due to the regulatory roles it performs in …

[HTML][HTML] Immunosuppressive property of MSCs mediated by cell surface receptors

S Liu, F Liu, Y Zhou, B Jin, Q Sun, S Guo - Frontiers in immunology, 2020 - frontiersin.org
In the past decade, mesenchymal stem cells (MSCs) tend to exhibit inherent tropism for
refractory inflammatory diseases and engineered MSCs have appeared on the market as …

Dual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms

HM Wobma, M Kanai, SP Ma, Y Shih, HW Li… - Journal of immunology …, 2018 - Elsevier
The immunosuppressive capacity of human mesenchymal stromal cells (MSCs) renders
them promising candidates for treating diverse immune disorders. However, after hundreds …

Dietary fiber as a wide pillar of colorectal cancer prevention and adjuvant therapy

LF Pedrosa, JP Fabi - Critical Reviews in Food Science and …, 2024 - Taylor & Francis
Colorectal cancer is the third most incident and second most lethal type of cancer worldwide.
Lifestyle and dietary patterns are the key factors for higher disease development risk. The …

Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption

L Zhu, Y Tang, XY Li, SA Kerk, CA Lyssiotis… - Journal of Cell …, 2023 - rupress.org
Bone-resorbing osteoclasts mobilize proteolytic enzymes belonging to the matrix
metalloproteinase (MMP) family to directly degrade type I collagen, the dominant …

Galectin‐3 Knockdown Impairs Survival, Migration, and Immunomodulatory Actions of Mesenchymal Stromal Cells in a Mouse Model of Chagas Disease …

BSF Souza, KN Silva, DN Silva… - Stem cells …, 2017 - Wiley Online Library
Therapies based on transplantation of mesenchymal stromal cells (MSC) hold promise for
the management of inflammatory disorders. In chronic Chagas disease cardiomyopathy …

[HTML][HTML] Role of MSC-derived galectin 3 in the AML microenvironment

PP Ruvolo, VR Ruvolo, JK Burks, YH Qiu… - … et Biophysica Acta (BBA …, 2018 - Elsevier
In acute myeloid leukemia (AML), high Galectin 3 (LGALS3) expression is associated with
poor prognosis. The role of LGALS3 derived from mesenchymal stromal cells (MSC) in the …

[HTML][HTML] Construction of the panoptosis-related gene model and characterization of tumor microenvironment infiltration in hepatocellular carcinoma

X Shi, X Gao, W Liu, X Tang, J Liu, D Pan… - Oncology …, 2023 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is the most common fatal cancer worldwide, patients with
HCC have a high mortality rate and poor prognosis. PANoptosis is a novel discovery of …

[HTML][HTML] Inhibition of LPS-Induced Inflammatory Response of Oral Mesenchymal Stem Cells in the Presence of Galectin-3

A Paganelli, F Diomede, GD Marconi, J Pizzicannella… - Biomedicines, 2023 - mdpi.com
Galectin-3 (GAL-3) is a beta-galactoside binding lectin produced by mesenchymal stem
cells (MSCs) and other cell sources under inflammatory conditions. Several studies have …