Since its discovery as a primary component in cytoplasmic aggregates in post-mortem tissue
of patients with Amyotrophic Lateral Sclerosis (ALS), TAR DNA Binding Protein 43 kDa (TDP …

Cytoplasmic aggregation of TAR DNA-binding protein 43 (TDP43; also known as TARDBP
or TDP-43) is a key pathological feature of several neurodegenerative diseases, including …

Alzheimer's disease (AD) is behaviorally identified by progressive memory impairment and
pathologically characterized by the triad of β-amyloid plaques, neurofibrillary tangles, and …

Transactive response DNA binding protein of 43 kDa (TDP-43) is an intranuclear protein
encoded by the TARDBP gene that is involved in RNA splicing, trafficking, stabilization, and …

Breakthrough discoveries identifying common genetic causes for amyotrophic lateral
sclerosis (ALS) and frontotemporal dementia (FTD) have transformed our view of these …

Mechanisms of protein homeostasis are crucial for overseeing the clearance of misfolded
and toxic proteins over the lifetime of an organism, thereby ensuring the health of neurons …

The causes of multiple sclerosis and amyotrophic lateral sclerosis have long remained
elusive. A new category of pathogenic components, normally dormant within human …

The stereotypical distribution of TAR DNA-binding 43 protein (TDP-43) aggregates in
frontotemporal lobar degeneration (FTLD-TDP) suggests that pathological TDP-43 spreads …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the
aggregation of ubiquitinated proteins in affected motor neurons. Recent studies have …

The molecular processes that contribute to degenerative diseases are not well understood.
Recent observations suggest that some degenerative diseases are promoted by the …