Drugs of abuse share with conventional reinforcers the activation of specific neural
pathways in the CNS that are the substrate of their motivational properties. Dopamine is …

Dopamine has been proposed to mediate some of the behavioral effects of caffeine. This
review discusses cellular mechanisms of action that could explain the role of dopamine in …

Activation of the mesolimbic dopamine system is known to trigger relapse in animal models
of cocaine-seeking behavior. We found that this “priming” effect was selectively induced by …

In the adult mouse, single and compound null mutations in the genes for retinoic acid
receptor β and retinoid X receptors β and γ resulted in locomotor defects related to …

The brain mesoaccumbens dopamine system is intricately involved in the psychomotor
stimulant activities of cocaine. However, the extent to which different dopamine receptors …

These studies investigated the effects of antagonists selective for the 5-HT2A, 5-HT2B, or 5-
HT2C receptor subtypes on behaviors elicited or maintained by cocaine. The selective 5 …

Psychostimulants are a broadly defined class of drugs that stimulate the central and
peripheral nervous systems as their primary pharmacological effect. The abuse liability of …

Over the past several decades, there have been tremendous advances in our understanding
of the neurobiology of drug addiction. Much of this work has focused on the neurobiological …

A balanced conditioning place preference (CPP) paradigm was used to study the role of
dopamine D1 and D2 and glutamatergic NMDA and AMPA/kainate receptors on the …

Insights into the Role of Dopamine Receptor Systems in Learning and Memory Page 1 ©
Freund & Pettman, UK Reviews in the Neurosciences, 18, 37-66 (2007) Insights into the Role …