Hyperglycemia plays an important role in the pathogenesis of type 2 diabetes mellitus, ie,
glucotoxicity, and it also is the major risk factor for microvascular complications. Thus …

Lower extremity ulcers represent a major concern for patients with diabetes and for those
who treat them, from both a quality of life and an economic standpoint. Studies to evaluate …

Insulin resistance is a major factor in the pathogenesis of type 2 diabetes in the elderly. To
investigate how insulin resistance arises, we studied healthy, lean, elderly and young …

Task Forces, expert groups, or consensus panels. The chosen experts in these writing
panels are asked to provide disclosure statements of all relationships they may have, which …

OBJECTIVE—The utility of rapid and reliable sensory tests appropriate for the diagnosis of
neuropathy in the diabetes clinic, rather than as prognostic tools for the prediction of foot …

To determine the relation of body mass index (weight/height2) with the risk of clinical non-
insulin-dependent diabetes, the authors analyzed data from a cohort of 113,861 US women …

In this paper the Rotterdam Elderly Study is presented. The aim of the study is to investigate
determinants of disease occurrence and progression in the elderly. In addition to …

Purpose The purpose of this paper is to assess the economic costs of inactivity (including
those attributable to obesity). These costs represent one summary of the public health …

Background Obesity is an established risk factor for several chronic diseases. The lifetime
health and economic consequences of obesity for individual patients have not been …

Diabetic foot ulcers and lower-extrem-ity amputations are serious and expensive
complications that befall up to 15% of people with diabetes during their lifetime. Relatively …