Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

Glutamate receptor-mediated excitatory neurotransmission plays a key role in neural
development, differentiation and synaptic plasticity. However, excessive stimulation of …

Alzheimer's disease (AD) includes etiologically heterogenous disorders characterized by
senile or presenile dementia, extracellular amyloid protein aggregations containing an …

β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying
Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study …

Alzheimer's disease (AD) is characterized by memory impairment, neurochemically by
accumulation of β-amyloid peptide (namely Aβ1-42) and morphologically by an initial loss of …

Nosologically, Alzheimer disease is not a single disorder in spite of a common clinical
phenotype. Etiologically, two different types or even more exist.(1) In a minority of about 5 …

Morphological alterations of mitochondria may be related to metabolic and energy
deficiency in neurons in Alzheimer's disease and other neurodegenerative disorders …

The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially
with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer …

Impaired brain energy metabolism and oxidative stress are implicated in cognitive decline
and the pathologic accumulations of amyloid β-peptide (Aβ) and hyperphosphorylated tau in …

Synaptic dysfunction and failure are processes that occur early in Alzheimer disease (AD)
and are important targets for protective treatments to slow AD progression and preserve …