Microenvironment-responsive nanocarriers for targeted bone disease therapy

M Li, B Yu, S Wang, F Zhou, J Cui, J Su - Nano Today, 2023 - Elsevier
Nanomedicines with controlled drug release have received increasing attention as an
advanced therapeutic strategy for bone diseases. To traverse biological barriers towards …

Non-viral nucleic acid delivery approach: A boon for state-of-the-art gene delivery

KK Sahu, M Pradhan, D Singh, MR Singh… - Journal of Drug Delivery …, 2023 - Elsevier
An increasing number of gene therapy applications necessitate the use of delivery methods
that are risk-free, highly effective, highly targeted, and do not cause any threat to the …

肿瘤类器官及其在合成生物学中的研究进展

孟倩, 尹聪, 黄卫人 - 合成生物学, 2024 - synbioj.cip.com.cn
类器官技术的发展为更接近机体细胞组成和病理生理特征的癌症模型开辟了新途径.
患者来源的肿瘤类器官在多次传代后仍能维持原有肿瘤的组织病理学及遗传表型特征 …

Intersection of nanomaterials and organoids technology in biomedicine

C Shen, Z Zhang, X Li, Y Huang, Y Wang… - Frontiers in …, 2023 - frontiersin.org
Organoids are stem cell-derived, self-organizing, 3D structures. Compared to the
conventional 2D cell culture method, 3D cultured organoids contain a variety of cell types …

Polarity-wise successive solvent extraction of Scenedesmus obliquus biomass and characterization of the crude extracts for broad-spectrum antibacterial activity

C Mukherjee, PG Suryawanshi, MC Kalita… - Biomass Conversion …, 2024 - Springer
The present research aims to exploit the antioxidant and antibacterial activities of freshwater
microalgae, Scenedesmus obliquus, by performing polarity-wise successive solvent …

[HTML][HTML] Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures

R Issa, N Lozano, K Kostarelos, S Vranic - Nano Today, 2024 - Elsevier
Human lung organoids (HLOs) are increasingly used to model development and infectious
diseases, however their ability to recapitulate functional pulmonary tissue response to …

Nanomaterials in Organoids: From Interactions to Personalized Medicine

Y Shi, X Han, S Zou, G Liu - ACS nano, 2024 - ACS Publications
Organoids are three-dimensional models of microscopic organisms created through the self-
organization of various types of stem cells. They are widely unitized in personalized …

Multiscale engineering of brain organoids for disease modeling

C Xu, A Alameri, W Leong, E Johnson, Z Chen… - Advanced Drug Delivery …, 2024 - Elsevier
Brain organoids hold great potential for modeling human brain development and
pathogenesis. They recapitulate certain aspects of the transcriptional trajectory, cellular …

类器官在肿瘤转化医学中的应用和进展

王若彤, 王欣, 沈波 - 中国癌症杂志, 2022 - china-oncology.com
随着精准医学概念的提出, 肿瘤作为一类高度异质性的疾病, 其个体化治疗已成为精准医学的
一个关键领域也受到更多关注. 近期提出的类器官模型为肿瘤的基础研究和个体化治疗带来了新 …

Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration

Y Wu, L Li, Z Ning, C Li, Y Yin, K Chen, L Li… - Cell Communication and …, 2024 - Springer
Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue
regeneration by regulating inflammation, reducing oxidative stress and promoting cell …