Mechanisms of nausea and vomiting: current knowledge and recent advances in intracellular emetic signaling systems

W Zhong, O Shahbaz, G Teskey, A Beever… - International journal of …, 2021 - mdpi.com
Nausea and vomiting are common gastrointestinal complaints that can be triggered by
diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and …

Neuropeptide Y: A stressful review

F Reichmann, P Holzer - Neuropeptides, 2016 - Elsevier
Stress is defined as an adverse condition that disturbs the homeostasis of the body and
activates adaptation responses. Among the many pathways and mediators involved …

Dynamics of gut-brain communication underlying hunger

LR Beutler, Y Chen, JS Ahn, YC Lin, RA Essner… - Neuron, 2017 - cell.com
Communication between the gut and brain is critical for homeostasis, but how this
communication is represented in the dynamics of feeding circuits is unknown. Here we …

Therapeutic potential of neuropeptide Y (NPY) receptor ligands

SP Brothers, C Wahlestedt - EMBO molecular medicine, 2010 - embopress.org
Neuropeptide Y (NPY) is widely distributed in the human body and contributes to a vast
number of physiological processes. Since its discovery, NPY has been implicated in …

The role of NPY in hypothalamic mediated food intake

RE Mercer, MJS Chee, WF Colmers - Frontiers in neuroendocrinology, 2011 - Elsevier
Neuropeptide Y (NPY) is a highly conserved neuropeptide with orexigenic actions in
discrete hypothalamic nuclei that plays a role in regulating energy homeostasis. NPY …

Neuropeptide Y receptors: how to get subtype selectivity

X Pedragosa-Badia, J Stichel… - Frontiers in …, 2013 - frontiersin.org
The neuropeptide Y (NPY) system is a multireceptor/multiligand system consisting of four
receptors in humans (hY1, hY2, hY4, hY5) and three agonists (NPY, PYY, PP) that activate …

Neuropeptide Y and posttraumatic stress disorder

R Sah, TD Geracioti - Molecular psychiatry, 2013 - nature.com
Resiliency to the adverse effects of extraordinary emotional trauma on the brain varies within
the human population. Accordingly, some people cope better than others with traumatic …

Neuropeptide Y, resilience, and PTSD therapeutics

M Kautz, DS Charney, JW Murrough - Neuroscience letters, 2017 - Elsevier
Resilience to traumatic stress is a complex psychobiological process that protects
individuals from developing posttraumatic stress disorder (PTSD) or other untoward …

Selective stimulation of colonic L cells improves metabolic outcomes in mice

JE Lewis, EL Miedzybrodzka, RE Foreman… - Diabetologia, 2020 - Springer
Aims/hypothesis Insulin-like peptide-5 (INSL5) is found only in distal colonic L cells, which
co-express glucagon-like peptide-1 (GLP-1) and peptide YY (PYY). GLP-1 is a well-known …

Neuropeptide Y (NPY) and posttraumatic stress disorder (PTSD): a translational update

SN Schmeltzer, JP Herman, R Sah - Experimental neurology, 2016 - Elsevier
Posttraumatic stress disorder (PTSD) is a trauma-evoked syndrome, with variable
prevalence within the human population due to individual differences in coping and …