Changes in CSF sPDGFRβ level and their association with blood–brain barrier breakdown in Alzheimer's disease with or without small cerebrovascular lesions
X Lv, M Zhang, Z Cheng, Q Wang, P Wang… - Alzheimer's Research & …, 2023 - Springer
Background CSF-soluble platelet-derived growth factor receptor beta (sPDGFRβ) is closely
associated with pericyte damage. However, the changes in CSF sPDGFRβ levels and their …
associated with pericyte damage. However, the changes in CSF sPDGFRβ levels and their …
How do modifiable risk factors affect Alzheimer's disease pathology or mitigate its effect on clinical symptom expression?
Epidemiological studies show that modifiable risk factors account for about 40% of the
population variability in risk of developing dementia, including sporadic Alzheimer's disease …
population variability in risk of developing dementia, including sporadic Alzheimer's disease …
[HTML][HTML] Physical activity and amyloid beta in middle-aged and older adults: A systematic review and meta-analysis
M Rodriguez-Ayllon, P Solis-Urra… - Journal of sport and …, 2023 - Elsevier
Background One of the pathological hallmarks distinguishing Alzheimer's disease from other
dementias is the accumulation of amyloid beta (Aβ). Higher physical activity is associated …
dementias is the accumulation of amyloid beta (Aβ). Higher physical activity is associated …
Understanding the relationship between type-2 diabetes, MRI markers of neurodegeneration and small vessel disease, and dementia risk: a mediation analysis
L Grasset, E Frison, C Helmer, G Catheline… - European Journal of …, 2024 - Springer
To explore to which extent neurodegeneration and cerebral small vessel disease (SVD)
could mediate the association between type-2 diabetes and higher dementia risk. The …
could mediate the association between type-2 diabetes and higher dementia risk. The …
Elevated late-life blood pressure may maintain brain oxygenation and slow amyloid-β accumulation at the expense of cerebral vascular damage
HM Tayler, R MacLachlan, Ö Güzel… - Brain …, 2023 - academic.oup.com
Hypertension in midlife contributes to cognitive decline and is a modifiable risk factor for
dementia. The relationship between late-life hypertension and dementia is less clear. We …
dementia. The relationship between late-life hypertension and dementia is less clear. We …
The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer's disease continuum …
Background Glymphatic dysfunction is a crucial pathway for dementia. Alzheimer's disease
(AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common …
(AD) pathologies co-existing with cerebral small vessel disease (CSVD) is the most common …
Arterial hypertension and β-amyloid accumulation have spatially overlapping effects on posterior white matter hyperintensity volume: a cross-sectional study
J Bernal, S Schreiber, I Menze, A Ostendorf… - Alzheimer's research & …, 2023 - Springer
Background White matter hyperintensities (WMH) in subjects across the Alzheimer's disease
(AD) spectrum with minimal vascular pathology suggests that amyloid pathology—not just …
(AD) spectrum with minimal vascular pathology suggests that amyloid pathology—not just …
Association between brain amyloid deposition and longitudinal changes of white matter hyperintensities
WJ Cha, D Yi, H Ahn, MS Byun, YY Chang… - Alzheimer's Research & …, 2024 - Springer
Background Growing evidence suggests that not only cerebrovascular disease but also
Alzheimer's disease (AD) pathological process itself cause cerebral white matter …
Alzheimer's disease (AD) pathological process itself cause cerebral white matter …
Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration
R Boyle, DL Townsend, HM Klinger… - Alzheimer's Research & …, 2024 - Springer
Abstract Background Leveraging Alzheimer's disease (AD) imaging biomarkers and
longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to …
longitudinal cognitive data may allow us to establish evidence of cognitive resilience (CR) to …
Updating the study protocol: Insight 46–a longitudinal neuroscience sub-study of the MRC National Survey of Health and Development–phases 2 and 3
H Murray-Smith, S Barker, F Barkhof, J Barnes… - BMC neurology, 2024 - Springer
Background Although age is the biggest known risk factor for dementia, there remains
uncertainty about other factors over the life course that contribute to a person's risk for …
uncertainty about other factors over the life course that contribute to a person's risk for …