In adult mammals, massive sudden loss of cardiomyocytes after infarction overwhelms the
limited regenerative capacity of the myocardium, resulting in the formation of a collagen …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Our body handles tissue damage by activating the immune system in response to
intracellular molecules released by injured tissues [damage-associated molecular patterns …

Complex genetic and physiological variations as well as environmental factors that drive
emergence of chromosomal instability, development of unscheduled cell death, skewed …

A single protein, HMGB 1, directs the triggering of inflammation, innate and adaptive
immune responses, and tissue healing after damage. HMGB 1 is the best characterized …

Objective: Neutrophil extracellular traps (NETs) produced by tumor-infiltrating neutrophils
(TINs) are associated with poor prognosis in patients with several types of cancer. However …

Myocardial infarction is defined as sudden ischemic death of myocardial tissue. In the
clinical context, myocardial infarction is usually due to thrombotic occlusion of a coronary …

Alarmins are endogenous molecules that are constitutively available and released upon
tissue damage and activate the immune system. Current evidence indicates that …

Multicellular animals detect pathogens via a set of receptors that recognize pathogen-
associated molecular patterns (PAMPs). However, pathogens are not the only causative …

Abstract Aims Circulating microRNAs (miRNAs) may represent a novel class of biomarkers;
therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma …