Innovations and advances in modelling and measuring pain in animals

KE Sadler, JS Mogil, CL Stucky - Nature Reviews Neuroscience, 2022 - nature.com
Best practices in preclinical algesiometry (pain behaviour testing) have shifted over the past
decade as a result of technological advancements, the continued dearth of translational …

Post-injury pain and behaviour: a control theory perspective

B Seymour, RJ Crook, ZS Chen - Nature Reviews Neuroscience, 2023 - nature.com
Injuries of various types occur commonly in the lives of humans and other animals and lead
to a pattern of persistent pain and recuperative behaviour that allows safe and effective …

Mapping the neuroethological signatures of pain, analgesia, and recovery in mice

M Bohic, LA Pattison, ZA Jhumka, H Rossi… - Neuron, 2023 - cell.com
Ongoing pain is driven by the activation and modulation of pain-sensing neurons, affecting
physiology, motor function, and motivation to engage in certain behaviors. The complexity of …

Keratinocyte PIEZO1 modulates cutaneous mechanosensation

AR Mikesell, O Isaeva, F Moehring, KE Sadler… - Elife, 2022 - elifesciences.org
Epidermal keratinocytes mediate touch sensation by detecting and encoding tactile
information to sensory neurons. However, the specific mechanotransducers that enable …

[HTML][HTML] Touch neurons underlying dopaminergic pleasurable touch and sexual receptivity

LJ Elias, IK Succi, MD Schaffler, W Foster, MA Gradwell… - Cell, 2023 - cell.com
Pleasurable touch is paramount during social behavior, including sexual encounters.
However, the identity and precise role of sensory neurons that transduce sexual touch …

[HTML][HTML] Machine learning and artificial intelligence in neuroscience: A primer for researchers

F Badrulhisham, E Pogatzki-Zahn, D Segelcke… - Brain, Behavior, and …, 2024 - Elsevier
Artificial intelligence (AI) is often used to describe the automation of complex tasks that we
would attribute intelligence to. Machine learning (ML) is commonly understood as a set of …

Lightning Pose: improved animal pose estimation via semi-supervised learning, Bayesian ensembling and cloud-native open-source tools

D Biderman, MR Whiteway, C Hurwitz, N Greenspan… - Nature …, 2024 - nature.com
Contemporary pose estimation methods enable precise measurements of behavior via
supervised deep learning with hand-labeled video frames. Although effective in many cases …

[HTML][HTML] Bridging skin, brain, and behavior to understand pleasurable social touch

LJ Elias, I Abdus-Saboor - Current Opinion in Neurobiology, 2022 - Elsevier
Social touch—the affiliative skin-to-skin contact between individuals—can rapidly evoke
emotions of comfort, pleasure, or calm, and is essential for mental and physical well-being …

[HTML][HTML] Automated preclinical detection of mechanical pain hypersensitivity and analgesia

Z Zhang, DP Roberson, M Kotoda, B Boivin… - Pain, 2022 - journals.lww.com
The lack of sensitive and robust behavioral assessments of pain in preclinical models has
been a major limitation for both pain research and the development of novel analgesics …

Roundness Holes' Measurement for milled workpiece using machine vision inspection system based on IoT structure: A case study

Y Saif, Y Yusof, K Latif, AZA Kadir, M binti lliyas Ahmed… - Measurement, 2022 - Elsevier
Manufacturing Metrology is a vital aspect of the sophisticated industrial 4.0-based
manufacturing industry, as practically everything machined with certain metrological systems …