Nucleoside analogs play a crucial role in the production of high-value antitumor and
antimicrobial drugs. Currently, nucleoside analogs are mainly obtained through nucleic acid …

Phosphate metabolites (PMs) are endogenous substances that contain phosphate groups,
constituting over half of the small molecules in the body. They play crucial roles in various …

Methylthioadenosine phosphorylase, an essential enzyme for the adenine salvage pathway,
is often deficient (MTAPdef) in tumors with 9p21 loss and hypothetically renders tumors …

Background Since non-alcoholic fatty liver disease (NAFLD) pathogenesis is multi-factorial,
pharmacotherapy with a specific target commonly exhibits limited efficacy. Phytotherapy …

Polar phosphorylated metabolites are involved in a variety of biological processes and play
vital roles in energetic metabolism, cofactor regeneration, and nucleic acid synthesis …

Hydrophilic metabolites play important roles in cellular energy metabolism, signal
transduction, immunity. However, there are challenges in both identification and …

Ribonucleotide analogues and their related phosphorylated metabolites play critical roles in
tumor metabolism. However, determination of the endogenous ribonucleotides from the …

The discovery of RNA silencing has revealed that non‐protein‐coding sequences (ncRNAs)
can cover essential roles in regulatory networks and their malfunction may result in severe …

Alterations of DNA repair enzymes and consequential triggering of aberrant DNA damage
response (DDR) pathways are thought to play a pivotal role in genomic instabilities …

Highlights•Gas–solid phase derivatization (GSPD) as a novel gas-phase derivatization for
GC-MS-based metabolomics was proposed.•GSPD methods for organic acids and sugar …