Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …

The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …

Fifteen years ago, the drive to study retroviruses was rooted principally in the traditional goal
of using animal models to understand human cancer. The historical importance of …

The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …

Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of
skeletal elements, yet little is known about the molecular regulation of this process. A …

Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located …

Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …

Resistance to the ABL kinase inhibitor imatinib (STI571 or Gleevec) in chronic myeloid
leukemia (CML) occurs through selection for tumor cells harboring BCR-ABL kinase domain …

Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in
common certain structural characteristics, and most of whom bind heparin avidly. Many …

A recurrent theme in embryonic development and tissue regeneration is that cells
communicate with each other using just a handful of conserved families of signaling …