Hedgehog signaling in animal development: paradigms and principles
PW Ingham, AP McMahon - Genes & development, 2001 - genesdev.cshlp.org
Since their isolation in the early 1990s, members of the Hedgehog family of intercellular
signaling proteins have come to be recognized as key mediators of many fundamental …
signaling proteins have come to be recognized as key mediators of many fundamental …
Hedgehog: functions and mechanisms
M Varjosalo, J Taipale - Genes & development, 2008 - genesdev.cshlp.org
The Hedgehog (Hh) family of proteins control cell growth, survival, and fate, and pattern
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …
almost every aspect of the vertebrate body plan. The use of a single morphogen for such a …
Retroviruses
JM Coffin, SH Hughes, HE Varmus - 1997 - pubmed.ncbi.nlm.nih.gov
Fifteen years ago, the drive to study retroviruses was rooted principally in the traditional goal
of using animal models to understand human cancer. The historical importance of …
of using animal models to understand human cancer. The historical importance of …
Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome
RL Johnson, AL Rothman, J Xie, LV Goodrich, JW Bare… - Science, 1996 - science.org
The basal cell nevus syndrome (BCNS) is characterized by developmental abnormalities
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …
and by the postnatal occurrence of cancers, especially basal cell carcinomas (BCCs), the …
Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein
A Vortkamp, K Lee, B Lanske, GV Segre… - Science, 1996 - science.org
Proper regulation of chondrocyte differentiation is necessary for the morphogenesis of
skeletal elements, yet little is known about the molecular regulation of this process. A …
skeletal elements, yet little is known about the molecular regulation of this process. A …
A Switch Between Topological Domains Underlies HoxD Genes Collinearity in Mouse Limbs
G Andrey, T Montavon, B Mascrez, F Gonzalez… - Science, 2013 - science.org
Introduction During vertebrate limb development, gene members of the HoxD cluster are
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located …
transcribed in two subsequent waves, following a collinear strategy. Early on, genes located …
[HTML][HTML] Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation by regulating Fgfr2 and Fgfr3
T Kawane, X Qin, Q Jiang, T Miyazaki, H Komori… - Scientific reports, 2018 - nature.com
Runx2 and Sp7 are essential transcription factors for osteoblast differentiation. However, the
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …
molecular mechanisms responsible for the proliferation of osteoblast progenitors remain …
Overriding imatinib resistance with a novel ABL kinase inhibitor
NP Shah, C Tran, FY Lee, P Chen, D Norris… - Science, 2004 - science.org
Resistance to the ABL kinase inhibitor imatinib (STI571 or Gleevec) in chronic myeloid
leukemia (CML) occurs through selection for tumor cells harboring BCR-ABL kinase domain …
leukemia (CML) occurs through selection for tumor cells harboring BCR-ABL kinase domain …
Fibroblast growth factors, their receptors and signaling.
CJ Powers, SW McLeskey… - Endocrine-related …, 2000 - erc.bioscientifica.com
Fibroblast growth factors (FGFs) are small polypeptide growth factors, all of whom share in
common certain structural characteristics, and most of whom bind heparin avidly. Many …
common certain structural characteristics, and most of whom bind heparin avidly. Many …
[PDF][PDF] Bone morphogenetic proteins: multifunctional regulators of vertebrate development.
BL Hogan - Genes & development, 1996 - scholar.archive.org
A recurrent theme in embryonic development and tissue regeneration is that cells
communicate with each other using just a handful of conserved families of signaling …
communicate with each other using just a handful of conserved families of signaling …