CCAAT/enhancer-binding proteins (C/EBPs) are a family of at least six identified
transcription factors that contain a highly conserved basic leucine zipper domain and …

Tight junction (TJ) proteins establish a physical barrier between epithelial cells, playing a
crucial role in maintaining tissue homeostasis by safeguarding host tissues against …

Background Some COVID-19 survivors present lung function abnormalities during follow-up,
particularly reduced carbon monoxide lung diffusing capacity (DLCO). To investigate risk …

Acute lung injury (ALI) is still associated with high mortality. Growing evidence suggests that
Club Cell Protein 16 (CC16) plays a protective role against ALI. However, the doses of …

Rationale: CC16 is a protein mainly produced by nonciliated bronchial epithelial cells
(BECs) that participates in host defense. Reduced CC16 protein concentrations in BAL and …

Mucus and its movements are essential to epithelial tissue immune defenses against
pathogens, including fungal pathogens, which can infect respiratory, gastrointestinal or the …

Club Cell Secretory Protein (CC16) plays many protective roles within the lung; however, the
complete biological functions, especially regarding the pulmonary epithelium during …

Abstract Secretoglobin (SCGB) 3A2 was first identified in 2001 as a protein exhibiting
similarities in amino acid sequence and gene structure to SCGB1A1, a multi-functional …

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection was first
reported in Wuhan, China, and was declared a pandemic by the World Health Organization …

Background Proteomics can reveal molecular pathways of disease and provide translational
perspectives to inform clinical decision making. Although several studies have previously …