Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …

Sex and gender disparities in bladder cancer have long been a subject of interest to the
cancer research community, wherein men have a 4 times higher incidence rate than women …

Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …

Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …

Treatment with neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy is
the default treatment for muscle-invasive bladder cancer (BC). However, with the …

Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …

Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …

Heart failure affects millions of people worldwide, with men exhibiting a higher incidence
than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in …

Signaling rewiring allows tumors to survive therapy. Here we show that the decrease of the
master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer …

The tumor microenvironment (TME) is complex and involves many different cell types that
seemingly work together in helping cancer cells evade immune monitoring and survive …