Bladder cancer
L Dyrskjøt, DE Hansel, JA Efstathiou… - Nature Reviews …, 2023 - nature.com
Bladder cancer is a global health issue with sex differences in incidence and prognosis.
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …
Bladder cancer has distinct molecular subtypes with multiple pathogenic pathways …
[HTML][HTML] Biological differences underlying sex and gender disparities in bladder cancer: current synopsis and future directions
Sex and gender disparities in bladder cancer have long been a subject of interest to the
cancer research community, wherein men have a 4 times higher incidence rate than women …
cancer research community, wherein men have a 4 times higher incidence rate than women …
[HTML][HTML] An atlas of cells in the human tonsil
R Massoni-Badosa, S Aguilar-Fernández, JC Nieto… - Immunity, 2024 - cell.com
Palatine tonsils are secondary lymphoid organs (SLOs) representing the first line of
immunological defense against inhaled or ingested pathogens. We generated an atlas of …
immunological defense against inhaled or ingested pathogens. We generated an atlas of …
Hallmarks of sex bias in immuno-oncology: mechanisms and therapeutic implications
T Xiao, J Lee, TD Gauntner, M Velegraki… - Nature Reviews …, 2024 - nature.com
Sex differences are present across multiple non-reproductive organ cancers, with male
individuals generally experiencing higher incidence of cancer with poorer outcomes …
individuals generally experiencing higher incidence of cancer with poorer outcomes …
[HTML][HTML] The bladder cancer immune micro-environment in the context of response to immune checkpoint inhibition
J van Dorp, MS van der Heijden - Frontiers in immunology, 2023 - frontiersin.org
Treatment with neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy is
the default treatment for muscle-invasive bladder cancer (BC). However, with the …
the default treatment for muscle-invasive bladder cancer (BC). However, with the …
[HTML][HTML] Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease
Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …
alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that …
[HTML][HTML] Androgen drives melanoma invasiveness and metastatic spread by inducing tumorigenic fucosylation
Q Liu, E Adhikari, DK Lester, B Fang… - Nature …, 2024 - nature.com
Melanoma incidence and mortality rates are historically higher for men than women.
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …
Although emerging studies have highlighted tumorigenic roles for the male sex hormone …
Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure
K Horitani, NW Chavkin, Y Arai, Y Wang… - Nature Cardiovascular …, 2024 - nature.com
Heart failure affects millions of people worldwide, with men exhibiting a higher incidence
than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in …
than women. Our previous work has shown that mosaic loss of the Y chromosome (LOY) in …
[HTML][HTML] Master Transcription Factor Reprogramming Unleashes Selective Translation Promoting Castration Resistance and Immune Evasion in Lethal Prostate …
S Santasusagna, S Zhu, V Jawalagatti… - Cancer discovery, 2023 - AACR
Signaling rewiring allows tumors to survive therapy. Here we show that the decrease of the
master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer …
master regulator microphthalmia transcription factor (MITF) in lethal prostate cancer …
[HTML][HTML] The bladder tumor microenvironment components that modulate the tumor and impact therapy
MV Patwardhan, R Mahendran - International Journal of Molecular …, 2023 - mdpi.com
The tumor microenvironment (TME) is complex and involves many different cell types that
seemingly work together in helping cancer cells evade immune monitoring and survive …
seemingly work together in helping cancer cells evade immune monitoring and survive …