The adoptive transfer of T cells that are engineered to express chimeric antigen receptors
(CARs) has shown remarkable success in treating B cell malignancies but only limited …

Glioblastomas are the most common form of malignant primary brain tumor and an important
cause of morbidity and mortality. In recent years there have been important advances in …

Treatment of solid cancers with chimeric antigen receptor (CAR) T cells is plagued by the
lack of ideal target antigens that are both absolutely tumor specific and homogeneously …

Metastatic cancer remains an almost inevitably lethal disease,–. A better understanding of
disease progression and response to therapies therefore remains of utmost importance …

Focal chromosomal amplification contributes to the initiation of cancer by mediating
overexpression of oncogenes,–, and to the development of cancer therapy resistance by …

Oncogene amplification on extrachromosomal DNA (ecDNA) is a common event, driving
aggressive tumor growth, drug resistance and shorter survival. Currently, the impact of …

Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …

Extrachromosomal DNA (ecDNA) amplification promotes intratumoral genetic heterogeneity
and accelerated tumor evolution,–; however, its frequency and clinical impact are unclear …

Advances in our understanding of molecular mechanisms of tumorigenesis have translated
into knowledge-based therapies directed against specific oncogenic signaling targets …

Cancer is one of the leading causes of death worldwide. Several treatments are available for
cancer treatment, but many treatment methods are ineffective against multidrug-resistant …