Abandon the mouse research ship? Not just yet!
Many preclinical studies in critical care medicine and related disciplines rely on hypothesis-
driven research in mice. The underlying premise posits that mice sufficiently emulate …
driven research in mice. The underlying premise posits that mice sufficiently emulate …
Temporal changes in fibrinolysis following injury
Trauma patients present to the emergency department with a spectrum of fibrinolytic activity.
This wide variance in fibrinolysis activity is a complex multifactorial process impacted by the …
This wide variance in fibrinolysis activity is a complex multifactorial process impacted by the …
Endothelial dysfunction is a potential contributor to multiple organ failure and mortality in aged mice subjected to septic shock: preclinical studies in a murine model of …
Introduction The goal of the current study was to investigate the effect of aging on the
development of endothelial dysfunction in a murine model of sepsis, and to compare it with …
development of endothelial dysfunction in a murine model of sepsis, and to compare it with …
Pathways mediating resolution of inflammation: when enough is too much
JN Fullerton, AJ O'Brien, DW Gilroy - The Journal of pathology, 2013 - Wiley Online Library
Patients with critical illness, and in particular sepsis, are now recognized to undergo
unifying, pathogenic disturbances of immune function. Whilst scientific and therapeutic focus …
unifying, pathogenic disturbances of immune function. Whilst scientific and therapeutic focus …
Novel relationships between oxidative stress and angiogenesis-related factors in sepsis: New biomarkers and therapies
S Vera, R Martinez, JG Gormaz, A Gajardo… - Annals of …, 2015 - Taylor & Francis
Sepsis is a systemic uncontrolled inflammatory response in the presence of an infection. It
remains a major cause of morbidity and mortality in hospitalized patients. According to its …
remains a major cause of morbidity and mortality in hospitalized patients. According to its …
Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis
S Drechsler, KM Weixelbaumer, A Weidinger… - Intensive care medicine …, 2015 - Springer
Background The mechanisms of sepsis mortality remain undefined. While there is some
evidence of organ damage, it is not clear whether this damage alone is sufficient to cause …
evidence of organ damage, it is not clear whether this damage alone is sufficient to cause …
Delayed activation of PPAR-β/δ improves long-term survival in mouse sepsis: effects on organ inflammation and coagulation
D Busch, A Kapoor, P Rademann… - Innate …, 2018 - journals.sagepub.com
Activation of peroxisome proliferator-activated receptor (PPAR)-β/δ reduces tissue injury in
murine endotoxemia. We hypothesized that the PPAR-β/δ-agonist GW0742 improves long …
murine endotoxemia. We hypothesized that the PPAR-β/δ-agonist GW0742 improves long …
[HTML][HTML] Systemic inhibition and liver‐specific over‐expression of PAI‐1 failed to improve survival in all‐inclusive populations or homogenous cohorts of CLP mice
P Raeven, S Drechsler, KM Weixelbaumer… - Journal of Thrombosis …, 2014 - Elsevier
Background The role of plasminogen activator inhibitor type‐1 (PAI‐1) in abdominal sepsis
remains elusive. Objectives To study the influence of inhibition and over‐expression of PAI …
remains elusive. Objectives To study the influence of inhibition and over‐expression of PAI …
[HTML][HTML] “二次休克” 打击模型的建立
唐婉琦， 马晓媛， 杨雪， 马娓， 严军， 梁华平 - 2018 - html.rhhz.net
目的模拟临床创伤休克并发脓毒性休克的情况, 建立" 二次休克" 打击动物模型,
连续观察小鼠血压和生存情况, 为筛选抗休克药物提供实验动物模型. 方法采用双后肢股骨骨折 …
连续观察小鼠血压和生存情况, 为筛选抗休克药物提供实验动物模型. 方法采用双后肢股骨骨折 …