Drug repurposing in non-small cell lung carcinoma: old solutions for new problems

G Doumat, D Daher, MB Zerdan, N Nasra… - Current …, 2023 - mdpi.com
Lung cancer is the second most common cancer and the leading cause of cancer-related
deaths in 2022. The majority (80%) of lung cancer cases belong to the non-small cell lung …

Overcoming drug resistance in advanced prostate cancer by drug repurposing

HF Bahmad, T Demus, MM Moubarak, D Daher… - Medical …, 2022 - mdpi.com
Prostate cancer (PCa) is the second most common cancer in men. Common treatments
include active surveillance, surgery, or radiation. Androgen deprivation therapy and …

Cell biology meets cell metabolism: energy production is similar in stem cells and in cancer stem cells in brain and bone marrow

CJF van Noorden, B Breznik, M Novak… - … of Histochemistry & …, 2022 - journals.sagepub.com
Energy production by means of ATP synthesis in cancer cells has been investigated
frequently as a potential therapeutic target in this century. Both (an) aerobic glycolysis and …

Effects of lovastatin on brain cancer cells

E Amadasu, R Kang, A Usmani… - Cell …, 2022 - journals.sagepub.com
Although brain tumors occur less frequently than other forms of cancer, they have one of the
bleakest prognoses with low survival rates. The conventional treatment for brain tumors …

New Insights in ATP Synthesis as Therapeutic Target in Cancer and Angiogenic Ocular Diseases

CJF van Noorden, B Yetkin-Arik… - … of Histochemistry & …, 2024 - journals.sagepub.com
Lactate and ATP formation by aerobic glycolysis, the Warburg effect, is considered a
hallmark of cancer. During angiogenesis in non-cancerous tissue, proliferating stalk …

Related mechanisms, current treatments, and new perspectives in meningioma

G Inetas‐Yengin, OF Bayrak - Genes, Chromosomes and …, 2024 - Wiley Online Library
Meningiomas are non‐glial tumors that are the most common primary brain tumors in adults.
Although meningioma can possibly be cured with surgical excision, variations in …

Repurposed Effect of 177Lu-DOTATATE in the Treatment of Mantle Cell Lymphoma

MK Elajami, LP Burton, HF Bahmad, G Chaaya… - Current …, 2022 - mdpi.com
Mantle cell lymphoma (MCL) is an uncommon subcategory of non-Hodgkin lymphoma
(NHL). Pathogenesis primarily includes overexpression of CCND1 and SOX11 along with …