In this review, we shall outline the basic principles Ž. of circular dichroism CD and indicate
the types of structural information relevant to the study of the Ž. folding and unfolding or …

Intrinsically disordered proteins (IDPs) differ from “normal” ordered proteins at several levels,
structural, functional and conformational. Amino acid biases characteristic for IDPs …

To establish a framework for extrapolating the helix-forming properties of peptides from
TFE/H2O mixtures (TFE= 2, 2, 2-trifluoroethanol) back to water, the thermal unfolding curves …

Parkinson's disease involves the loss of dopaminergic neurons in the substantia nigra,
leading to movement disorders. The pathological hallmark of Parkinson's disease is the …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

Among various alcohols, those substituted with fluorine, such as 2, 2, 2-trifluoroethanol
(TFE) or 3, 3, 3, 3 ', 3 ', 3 '-hexafluoro-2-propanol (HFIP), have a marked potential to induce …

Publisher Summary This chapter deals with the structure of the molten globules of various
globular proteins revealed by the recent experimental studies. Recent advances in …

We use two simple models and the energy landscape perspective to study protein folding
kinetics. A major challenge has been to use the landscape perspective to interpret …

Intracellular proteinaceous inclusions (Lewy bodies and Lewy neurites) of α-synuclein are
pathological hallmarks of neurodegenerative diseases such as Parkinson's disease …

Alcohols denature the native state of proteins, and also stabilize the α‐helical conformation
in unfolded proteins and peptides. Among various alcohols, trifluoroethanol (TFE) and …