This article reviews the development of the immune response through neonatal, infant and
adult life, including pregnancy, ending with the decline in old age. A picture emerges of a …

Streptococcus pneumoniae is an infectious pathogen responsible for millions of deaths
worldwide. Diseases caused by this bacterium are classified as pneumococcal diseases …

The human immune system comprises cellular and molecular components designed to
coordinately prevent infection while avoiding potentially harmful inflammation and …

The immune system is designed to protect the host from infection and injury. However, when
an adaptive immune response continues unchecked in the brain, the proinflammatory innate …

Exiting from the largely sterile environment of the womb, the neonatal immune system is not
fully mature, and thus neonatal immune cells must simultaneously mount responses against …

Sepsis is the leading cause of death in children worldwide. Although the diagnosis and
management of sepsis in infants and children is largely influenced by studies done in adults …

Streptococcus agalactiae (Group B streptococcus, GBS) is highly adapted to humans, where
it is a normal constituent of the intestinal and vaginal flora. Yet, GBS has highly invasive …

Optimal functioning of the immune system is crucial to human health, and nutrition is one of
the major exogenous factors modulating different aspects of immune function. Currently, no …

Neonatal and adult neutrophils are distinctly different from one another due to well-defined
and documented deficiencies in neonatal cells, including impaired functions, reduced …

The ontogeny of immunity during early life is of high importance as it shapes the immune
system for the entire course of life. The microbiome and the environment contribute to the …