Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Naturally, in somatic cells chromosome ends (telomeres) shorten during each cell division.
This process ensures to limit proliferation of somatic cells to avoid malignant proliferation; …

Transcriptional reactivation of telomerase reverse transcriptase (TERT) reconstitutes
telomerase activity in the majority of human cancers. Here, we found that ectopic TERT …

The study was aimed at investigating the synergistic inhibitory effect of unique combinational
regimen of nanocapsulated Metformin (Met) and Curcumin (Cur) against T47D breast …

The review focuses on mechanistic evidence for the link between obesity and breast cancer.
According to the IARC study, there is sufficient evidence that obesity is closely related to a …

Hanahan and Weinberg introduced the “hallmarks of cancer” and typified essential
biological abilities acquired by human cancer. Since then, a growing understanding of …

It is well known that a decreased expression or inhibited activity of telomerase in cancer
cells is accompanied by an increased sensitivity to some drugs (eg, doxorubicin, cisplatin, or …

Metformin has recently received attention for its potential effects with respect to cancer
prevention and treatment. Nonetheless, the low bioavailability and short half-life of …

One of the hallmarks of malignant cell populations is the ability to undergo continuous
proliferation. This property allows clonal lineages to acquire sequential aberrations that can …

Our knowledge regarding the implications of melatonin in the therapy of numerous medical
conditions, including cancer is constantly expanding. Melatonin can variably affect cancer …