Intestinal stem cells at the bottom of crypts fuel the rapid renewal of the different cell types
that constitute a multitasking tissue. The intestinal epithelium facilitates selective uptake of …

The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …

Fibroblasts are important cells for the support of homeostatic tissue function. In inflammatory
diseases such as rheumatoid arthritis and inflammatory bowel disease, fibroblasts take on …

Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …

Systemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high
morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic …

Intestinal stem and progenitor cells replicate and differentiate in distinct compartments,
influenced by Wnt, BMP, and other subepithelial cues. The cellular sources of these signals …

Malignant cell growth is fueled by interactions between tumor cells and the stromal cells
composing the tumor microenvironment. The human liver is a major site of tumors and …

Intestinal epithelial cells derive from stem cells at the crypt base and travel along the crypt-
villus axis to die at the villus tip. The two dominant villus epithelial cell types, absorptive …

Signals from the surrounding niche drive proliferation and suppress differentiation of
intestinal stem cells (ISCs) at the bottom of intestinal crypts. Among sub-epithelial support …

Human gut development requires the orchestrated interaction of differentiating cell types.
Here, we generate an in-depth single-cell map of the developing human intestine at 6–10 …