Physiologically‐based pharmacokinetic (PBPK) modeling and simulation provides
mechanism‐based predictions of the pharmacokinetics of an active ingredient following its …

The skin is the main barrier between the internal body environment and the external one.
The characteristics of this barrier and its properties are able to modify and affect drug …

The pharmaceutical industry has never seen such a vast development in process analytical
methods as in the last decade. The application of near-infrared (NIR) and Raman …

Skin permeability is widely considered to be mechanistically implicated in chemically-
induced skin sensitization. Although many chemicals have been identified as skin …

The determination of Abraham descriptors for single ions is reviewed, and equations are
given for the partition of single ions from water to a number of solvents. These ions include …

Artificial neural networks (ANNs) technology models the pattern recognition capabilities of
the neural networks of the brain. Similarly to a single neuron in the brain, artificial neuron …

Traditional gunshot residue (GSR) analysis is based on detection of particulates formed from
metals found in the primer. Recent concerns regarding the interpretation of GSR evidence …

Purpose Predicting human skin permeability of chemical compounds accurately and
efficiently is useful for developing dermatological medicines and cosmetics. However …

Transdermal delivery of therapeutic amounts of vitamin D 3 is proposed to overcome its
variable oral bioavailability, especially for people who suffer from fat malabsorption. The …

Experimental values of permeability coefficients, as log K p, of chemical compounds across
human skin were collected by carefully screening the literature, and adjusted to 37° C for the …