The Role of Bezlotoxumab for the Prevention of Recurrent Clostridioides difficile Infections: A Review of the Current Literature and Paradigm Shift after 2021

ML Hyte, LJ Arphai, CJ Vaughn, SH Durham - Antibiotics, 2022 - mdpi.com
Clostridioides difficile infections (CDIs), and particularly recurrent infections, cause a
significant burden on the health-care system. Bezlotoxumab is a new agent for the …

[HTML][HTML] Fidaxomicin vs vancomycin for the treatment of a first episode of Clostridium difficile infection: a meta-analysis and systematic review

LA Al Momani, O Abughanimeh, B Boonpheng… - Cureus, 2018 - ncbi.nlm.nih.gov
Clostridium difficile infection (CDI) continues to possess a significant disease burden in the
United States (US) as well as all over the world. Given the increase in severity and …

Japanese clinical practice guidelines for management of Clostridioides (Clostridium) difficile infection

H Kunishima, H Ohge, H Suzuki, A Nakamura… - Journal of Infection and …, 2022 - jiac-j.com
Toxigenic culture and cytotoxicity assays are standard tests for detecting C. difficile infection
(CDI). Others include immunochromatographic strips, a rapid diagnostic test that detects …

Clinical complications in patients with primary and recurrent Clostridioides difficile infection: A real-world data analysis

P Feuerstadt, M Boules, L Stong… - SAGE open …, 2021 - journals.sagepub.com
Objective: Clostridioides difficile infection and recurrent C. difficile infection result in
substantial economic burden and healthcare resource use. Sepsis and bowel surgery are …

Total synthesis of tiacumicin A. Total synthesis, relay synthesis, and degradation studies of fidaxomicin (tiacumicin B, lipiarmycin A3)

H Hattori, E Kaufmann… - The Journal of …, 2018 - ACS Publications
The commercial macrolide antibiotic fidaxomicin was synthesized in a highly convergent
manner. Salient features of this synthesis include a β-selective noviosylation, a β-selective …

Non-antibiotic therapy for Clostridioides difficile infection: a review

J Yang, H Yang - Critical reviews in clinical laboratory sciences, 2019 - Taylor & Francis
Clostridioides difficile infection (CDI) is a common infectious disease that is mainly caused
by antibiotics. Antibiotic therapy is still the dominant treatment for CDI, although it is …

Fidaxomicin monotherapy versus standard therapy combined with bezlotoxumab for treating patients with Clostridioides difficile infection at high risk of recurrence: a …

R Escudero-Sanchez, A Muriel García… - Journal of …, 2022 - academic.oup.com
Background Both fidaxomicin and bezlotoxumab (used in combination with an antibiotic
against Clostridioides difficile) achieve reductions in recurrence rates of C. difficile infection …

Mortality, healthcare resource utilization, and cost among Medicare beneficiaries with Clostridioides difficile infection with and without sepsis

A Amin, WW Nelson, J Dreyfus… - Therapeutic …, 2022 - journals.sagepub.com
Objective: To describe mortality, healthcare resource utilization (HRU), and costs among
Medicare beneficiaries with primary Clostridioides difficile infection (pCDI) or recurrent CDI …

Hypoalbuminemia as predictor of recurrence of Clostridium difficile infection

D Knafl, MG Vossen, C Gerges, E Lobmeyr… - Wiener klinische …, 2019 - Springer
Summary Background Novel drugs for Clostridium difficile (C. difficile) infections have been
proven to reduce recurrent infections. Because of their high financial costs, identification of …

Hospital readmission with Clostridium difficile infection as a secondary diagnosis is associated with worsened outcomes and greater revenue loss relative to principal …

MD Zilberberg, BH Nathanson, S Marcella… - Medicine, 2018 - journals.lww.com
Hospital readmission with Clostridium difficile infection as... : Medicine Hospital readmission
with Clostridium difficile infection as a secondary diagnosis is associated with worsened …