Organisms of all domains of life use photoreceptor proteins to sense and respond to light.
The light-sensitivity of photoreceptor proteins arises from bound chromophores such as …

Congenital stationary night blindness (CSNB) refers to a group of genetically and clinically
heterogeneous retinal disorders. Seventeen different genes with more than 360 different …

Background The details of the functional interaction between G proteins and the G protein
coupled receptors (GPCRs) have long been subjected to extensive investigations with …

Selective coupling of G protein (heterotrimeric guanine nucleotide–binding protein)–coupled
receptors (GPCRs) to specific Gα-protein subtypes is critical to transform extracellular …

Rhodopsin is the photoreceptor in human rod cells responsible for dim-light vision. The
visual receptors are part of the large superfamily of G protein–coupled receptors (GPCRs) …

Structural studies of G protein-coupled receptors (GPCRs) gave insights into molecular
mechanisms of their action and contributed significantly to molecular pharmacology. This is …

G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins
that have gained relevance as biological targets for pharmaceutical drug design. Although …

Highlights•Active state structures of a μOR–nanobody complex determined to 2.3 Å
resolution.•The first GPCR–arrestin structure defines the arrestin–opsin interface.•Structure …

Until the late 1990s, class AG protein-coupled receptors (GPCRs) were believed to function
as monomers. Indirect evidence that they might internalize or even signal as dimers has …

G protein-coupled receptors (GPCRs) are flexible integral membrane proteins involved in
transmembrane signaling. Their involvement in many physiological processes makes them …