Non-canonical Golgi-compartmentalized Gβγ signaling: mechanisms, functions, and therapeutic targets
G protein Gβγ subunits are key mediators of G protein-coupled receptor (GPCR) signaling
under physiological and pathological conditions; their inhibitors have been tested for the …
under physiological and pathological conditions; their inhibitors have been tested for the …
Location bias contributes to functionally selective responses of biased CXCR3 agonists
DS Eiger, N Boldizsar, CC Honeycutt, J Gardner… - Nature …, 2022 - nature.com
Some G protein-coupled receptor (GPCR) ligands act as “biased agonists” that preferentially
activate specific signaling transducers over others. Although GPCRs are primarily found at …
activate specific signaling transducers over others. Although GPCRs are primarily found at …
Molecular regulation of PLCβ signaling
Phospholipase C (PLC) enzymes convert the membrane phospholipid phosphatidylinositol-
4, 5-bisphosphate (PIP2) into inositol-1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG) …
4, 5-bisphosphate (PIP2) into inositol-1, 4, 5-triphosphate (IP3) and diacylglycerol (DAG) …
[HTML][HTML] Sequence-directed concentration of G protein-coupled receptors in COPII vesicles
G protein-coupled receptors (GPCRs) constitute the largest superfamily of plasma
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
membrane signaling proteins. However, virtually nothing is known about their recruitment to …
Stimulation of adenosine A1 receptor prevents oxidative injury in H9c2 cardiomyoblasts: Role of Gβγ-mediated Akt and ERK1/2 signaling
S Mangmool, ETH Kyaw, N Nuamnaichati… - Toxicology and Applied …, 2022 - Elsevier
Oxidative stress causes cellular injury and damage in the heart primarily through apoptosis
resulting in cardiac abnormalities such as heart failure and cardiomyopathy. During …
resulting in cardiac abnormalities such as heart failure and cardiomyopathy. During …
The olfactory receptor OR51E2 activates ERK1/2 through the Golgi-localized Gβγ-PI3Kγ-ARF1 pathway in prostate cancer cells
The olfactory receptor OR51E2 is ectopically expressed in prostate tissues and regulates
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …
prostate cancer progression, but its function and regulation in oncogenic mitogen-activate …
GNB1 and obesity: Evidence for a correlation between haploinsufficiency and syndromic obesity
L Kleinendorst, O Abawi, N Vos… - Clinical …, 2024 - Wiley Online Library
Most patients with GNB1 encephalopathy have developmental delay and/or intellectual
disability, brain anomalies and seizures. Recently, two cases with GNB1 encephalopathy …
disability, brain anomalies and seizures. Recently, two cases with GNB1 encephalopathy …
ELMO1 deficiency reduces neutrophil chemotaxis in murine peritonitis
S Yu, X Geng, H Liu, Y Zhang, X Cao, B Li… - International Journal of …, 2023 - mdpi.com
Peritoneal inflammation remains a major cause of treatment failure in patients with kidney
failure who receive peritoneal dialysis. Peritoneal inflammation is characterized by an …
failure who receive peritoneal dialysis. Peritoneal inflammation is characterized by an …
Gβγ signaling regulates microtubule-dependent control of Golgi integrity
K Rajanala, PB Wedegaertner - Cellular signalling, 2023 - Elsevier
Gβγ subunits regulate several non-canonical functions at distinct intracellular organelles.
Previous studies have shown that Gβγ signaling at the Golgi is necessary to mediate …
Previous studies have shown that Gβγ signaling at the Golgi is necessary to mediate …
G protein gamma subunit, a hidden master regulator of GPCR signaling
Heterotrimeric G proteins (αβγ subunits) that are activated by G protein-coupled receptors
(GPCRs) mediate the biological responses of eukaryotic cells to extracellular signals. The α …
(GPCRs) mediate the biological responses of eukaryotic cells to extracellular signals. The α …