Importance of the field: Connexins (Cxs) and gap junctional intercellular communications
(GJICs) play roles in cancer development, growth and metastasis. Experimental studies …

Gap junctions and their connexin components are indispensable in mediating the cellular
coordination required for tissue and organ homeostasis. The critical nature of their existence …

Tamoxifen (TAM) resistance has indicated a significant challenge during endocrine therapy
for hormone-sensitive breast cancer. Thus, it is significant to elucidate the molecular events …

Tualang honey (TH) is rich in flavonoids and phenolic acids and has significant anticancer
activity against breast cancer cells comparable to the effect of tamoxifen (TAM), in vitro. The …

Growing evidence suggests dietary antioxidants reduce the risk of several cancers. Grape
seeds extracts (GSE) are a rich source of polyphenols known to have antioxidant …

Studies on biomedical applications of nanoparticles are growing with a rapid pace. In
medicine, nanoparticles may be the solution for multi-drug-resistance which is still a major …

The epithelium of multicellular organisms possesses a well-defined architecture, referred to
as polarity that coordinates the regulation of essential cell features. Polarity proteins are …

The mammary gland presents a valuable model for developmental studies, spanning the
embryonic stage through menarche to menopause. The dynamic remodeling of this gland is …

Gap junctions, membrane-based channels comprised of connexin proteins (Cxs), facilitate
direct communication among neighbouring cells and between cells and the extracellular …

Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA
and induce apoptosis. However, increasing reports of side effects and drug resistance …