Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Following initial successes in melanoma treatment, immunotherapy has rapidly become
established as a major treatment modality for multiple types of solid cancers, including a …

Background PD-1 blockade is highly effective in patients with mismatch repair-deficient or
microsatellite instability-high metastatic colorectal cancer. The role of single-agent PD-1 …

Background Metastatic DNA mismatch repair-deficient (dMMR)/microsatellite instability-high
(MSI-H) colorectal cancer has a poor prognosis after treatment with conventional …

Colorectal cancer (CRC) with deficient DNA mismatch repair (dMMR) is characterized by
hypermutation leading to abundant neoantigens that activate an antitumor immune …

Colorectal cancer is a heterogeneous disease that develops via stepwise accumulation of
well-characterized genetic and epigenetic alterations. We review the genetic changes …

Background The focus of tumour-specific antigen analyses has been on single nucleotide
variants (SNVs), with the contribution of small insertions and deletions (indels) less well …

Large-scale genomic characterization of tumors from prospective cohort studies may yield
new insights into cancer pathogenesis. We performed whole-exome sequencing of 619 …

How the genomic landscape of a tumor shapes and is shaped by anti-tumor immunity has
not been systematically explored. Using large-scale genomic data sets of solid tissue tumor …

Initial results by Le and colleagues, which were published in the June 25, 2015 issue of the
New England Journal of Medicine, report significant responses of cancers with microsatellite …