There is a high prevalence of painful diabetic polyneuropathy (pDPN) with around one-third
of all patients with diabetes suffering from pDPN. pDPN has debilitating consequences, with …

Objective To assess the benefits and harms of pregabalin in the management of neuropathic
pain. Design Rapid review and meta-analysis of phase III, randomised, placebo-controlled …

Many drugs are responsible, through different mechanisms, for peripheral oedema. Severity
is highly variable, ranging from slight oedema of the lower limbs to anasarca pictures as in …

Background Although recent studies have shown that botulinum toxin‐A (BTX‐A) has a
good analgesic effect on trigeminal neuralgia (TN) and peripheral neuropathic pain (PNP) …

Background Clinical trials have not yet compared the efficacy of capsaicin 8% patch with
current standard therapy in peripheral neuropathic pain (PNP). Objectives Head‐to‐head …

Context Patients with peripheral neuropathic pain (NP) may only achieve partial pain relief
with currently recommended first-line oral treatments, which are also associated with …

Introduction Neuropathic pain (NP) is caused by a lesion or disease of the somatosensory
system, which can severely impact patients' quality of life. The current-approved treatments …

Neuropathic pain (NP) can be challenging to treat effectively as analgesic pharmacotherapy
(MED) can reduce pain, but the majority of patients do not experience complete pain relief …

Osteoarthritis (OA) is the most prevalent arthritis worldwide and is characterized by chronic
pain and impaired physical function. We hypothesized that heightened pain in hand OA …

Pregabalin is a first-line treatment in all major international guidelines on the management
of painful diabetic neuropathy (pDPN). Treatment with pregabalin leads to a clinically …