Chronic pain affects one in five of the general population and is the third most important
cause of disability-adjusted life-years globally. Unfortunately, treatment remains inadequate …

Sensory fibers of the peripheral nervous system carry sensation from specific sense
structures or use different tissues and organs as receptive fields, and convey this information …

2. Methods We performed RNA-seq for hDRG and integratively analyzed the transcriptome
by comparing it with publicly available human and mouse RNA-seq data sets (sources …

Injury can lead to devastating and often untreatable chronic pain. While acute pain
perception (nociception) evolved more than 500 million years ago, virtually nothing is known …

Important insights into the selection pressures and core molecular modules contributing to
the evolution of pain-related processes have come from studies of nociceptive systems in …

The PRDM [PRDI-BFI (positive regulatory domain I-binding factor 1) and RIZ1
(retinoblastoma protein-interacting zinc finger gene 1) homologous domain containing] …

In humans, many cases of congenital insensitivity to pain (CIP) are caused by mutations of
components of the NGF/TrkA signaling pathway, which is required for survival and …

Pain is an increasing clinical challenge affecting about half the population, with a substantial
number of people suffering daily intense pain. Such suffering can be linked to the dramatic …

PRDM12 is a member of the PRDI-BF1 (positive regulatory domain I-binding factor 1)
homologous domain (PRDM)-containing protein family, a subfamily of Kruppel-like zinc …

2 SNPs were discovered in our previous genome-wide association study (GWAS): s58995. 1
(rs420767326 A> G) in MEF2B gene and OAR3_115712045. 1 (rs401775061 A> C) in …