Omega-3 lipid mediators: modulation of the M1/M2 macrophage phenotype and its protective role in chronic liver diseases

LA Videla, R Valenzuela, A Del Campo… - International Journal of …, 2023 - mdpi.com
The complex interplay between dietary factors, inflammation, and macrophage polarization
is pivotal in the pathogenesis and progression of chronic liver diseases (CLDs). Omega-3 …

Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development

MM Alba, B Ebright, B Hua, I Slarve, Y Zhou… - Frontiers in …, 2023 - frontiersin.org
Liver cancer is a malignancy developed from underlying liver disease that encompasses
liver injury and metabolic disorders. The progression from these underlying liver disease to …

[HTML][HTML] Maresin-1 prevents liver fibrosis by targeting Nrf2 and NF-κB, reducing oxidative stress and inflammation

MJ Rodríguez, M Sabaj, G Tolosa, F Herrera Vielma… - Cells, 2021 - mdpi.com
Liver fibrosis is a complex process characterized by the excessive accumulation of
extracellular matrix (ECM) and an alteration in liver architecture, as a result of most types of …

The role of resolvins, protectins and marensins in non-alcoholic fatty liver disease (NAFLD)

D Maciejewska-Markiewicz, E Stachowska… - Biomolecules, 2021 - mdpi.com
Increased triacylglycerols'(TAG) synthesis, insulin resistance, and prolonged liver lipid
storage might lead to the development of non-alcoholic fatty liver disease (NAFLD). Global …

Effects of statins on specialized pro-resolving mediators: An additional pathway leading to resolution of inflammation

S Radbakhsh, N Katsiki, RD Santos, DP Mikhailidis… - Metabolism, 2022 - Elsevier
Statins are a class of cholesterol-lowering drugs that inhibit 3-hydroxy-3-methylglutaryl
coenzyme A (HMG-CoA) reductase. Anti-inflammatory and antioxidant properties, as well as …

Interface between Resolvins and Efferocytosis in Health and Disease

F Mohammad-Rafiei, S Negahdari… - Cell Biochemistry and …, 2024 - Springer
Acute inflammation resolution acts as a vital process for active host response, tissue support,
and homeostasis maintenance, during which resolvin D (RvD) and E (RvE) as mediators …

[HTML][HTML] Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions

D Ağagündüz, Ö Yeşildemir, E Koçyiğit, T Koçak… - Nutrients, 2024 - mdpi.com
Oxylipins are oxidized fatty acids, both saturated and unsaturated, formed through pathways
that involve singlet oxygen or dioxygen-mediated oxygenation reactions and are primarily …

Exploring the Unique Role of Specialized Pro-Resolving Mediators in Cancer Therapeutics

KM Quinlivan, IV Howard, F Southan, RL Bayer… - Prostaglandins & Other …, 2024 - Elsevier
Unresolved chronic inflammation, a hallmark of cancer, promotes tumor growth and
metastasis in various cancer types. In contrast to blocking inflammation, stimulation of …

Eumelanin protects the liver against diethylnitrosamine-induced liver injury

F Altındağ, S Boğokşayan, S Bayram - Toxicology, 2022 - Elsevier
This study aims to evaluate in vivo protective effects of eumelanin (EU) on
diethylnitrosamine (DEN)-induced liver injury. Wistar albino male rats were divided into 6 …

Anti-inflammatory strategies for hepatic encephalopathy: preclinical studies

RPC Santos, ECB Toscano, MA Rachid - Arquivos de Neuro …, 2023 - SciELO Brasil
Hepatic encephalopathy (HE) is a potentially reversible neuropsychiatric syndrome. Often,
HE causes cognitive and motor dysfunctions due to an acute or chronic insufficiency of the …