Infections with flaviviruses, such as dengue, West Nile virus and the recently re-emerging
Zika virus, are an increasing and probably lasting global risk. This Review summarizes and …

Dengue virus is the pathogenic principle behind several medical conditions. The most
common disease caused by this virus is dengue fever, characterized by high fever and flu …

Rhodanines and related five-membered heterocycles with multiple heteroatoms have
recently gained a reputation of being unselective compounds that appear as “frequent …

Covalent ligand-target interactions offer significant pharmacological advantages. However,
off-target reactivity of the reactive groups, which usually have electrophilic properties, must …

Dengue fever is a severe, widespread, and neglected disease with more than 2 million
diagnosed infections per year. The dengue virus NS2B/NS3 protease (PR) represents a …

The NS2B/NS3 serine proteases of the Zika and Dengue flaviviruses are attractive targets
for the development of antiviral drugs. We report the synthesis and evaluation of a new …

A novel extracellular protease (SAPRH) was hyper-produced (9000 U/mL) from Bacillus
safensis RH12, a newly isolated enzyme from a Tunisian offshore oil field. The enzyme was …

Abstract NS2B-NS3 is a serine protease of the Dengue virus considered a key target in the
search for new antiviral drugs. In this study flavonoids were found to be inhibitors of NS2B …

The protease of dengue virus is a promising target for antiviral drug discovery. We here
report a new generation of peptide–hybrid inhibitors of dengue protease that incorporate N …

The dengue virus (DENV) and West Nile Virus (WNV) NS2B-NS3 proteases are attractive
targets for the development of dual-acting therapeutics against these arboviral pathogens …