The obese adipose tissue microenvironment in cancer development and progression

DF Quail, AJ Dannenberg - Nature Reviews Endocrinology, 2019 - nature.com
Obesity is associated with both increased cancer incidence and progression in multiple
tumour types, and is estimated to contribute to up to 20% of cancer-related deaths. These …

Physical activity, sedentary behaviour, diet, and cancer: an update and emerging new evidence

J Kerr, C Anderson, SM Lippman - The Lancet Oncology, 2017 - thelancet.com
The lifestyle factors of physical activity, sedentary behaviour, and diet are increasingly being
studied for their associations with cancer. Physical activity is inversely associated with and …

Cancer as a matter of fat: the crosstalk between adipose tissue and tumors

E Lengyel, L Makowski, J DiGiovanni, MG Kolonin - Trends in cancer, 2018 - cell.com
Obesity has been linked to the increased risk and aggressiveness of many types of
carcinoma. A state of chronic inflammation in adipose tissue (AT), resulting in genotoxic …

[HTML][HTML] Obesity, type 2 diabetes, and cancer risk

T Scully, A Ettela, D LeRoith, EJ Gallagher - Frontiers in oncology, 2021 - frontiersin.org
Obesity and type 2 diabetes have both been associated with increased cancer risk and are
becoming increasingly prevalent. Metabolic abnormalities such as insulin resistance and …

Association of body fat and risk of breast cancer in postmenopausal women with normal body mass index: a secondary analysis of a randomized clinical trial and …

NM Iyengar, R Arthur, JAE Manson… - JAMA …, 2019 - jamanetwork.com
Importance Obesity is associated with an increased risk of breast cancer, including the
estrogen receptor (ER)–positive subtype in postmenopausal women. Whether excess …

Estrogens and breast cancer: Mechanisms involved in obesity-related development, growth and progression

P Bhardwaj, CMC Au, A Benito-Martin… - The Journal of steroid …, 2019 - Elsevier
Obesity is a risk factor for estrogen receptor-positive (ER+) breast cancer after menopause.
The pro-proliferative effects of estrogens are well characterized and there is a growing body …

[HTML][HTML] Obesity and breast cancer: a case of inflamed adipose tissue

R Kolb, W Zhang - Cancers, 2020 - mdpi.com
Obesity is associated with an increased risk of estrogen receptor-positive breast cancer in
postmenopausal women and a worse prognosis for all major breast cancer subtypes …

[HTML][HTML] Molecular mechanisms of western diet-induced obesity and obesity-related carcinogenesis—A narrative review

D Lathigara, D Kaushal, RB Wilson - Metabolites, 2023 - mdpi.com
The present study aims to provide a narrative review of the molecular mechanisms of
Western diet-induced obesity and obesity-related carcinogenesis. A literature search of the …

The impact of obesity on breast cancer

DF Argolo, CA Hudis, NM Iyengar - Current oncology reports, 2018 - Springer
The rates of obesity are increasing worldwide and this condition is now recognized as a
leading preventable cause of cancer. Several diseases are directly related to obesity …

Obesity and breast cancer–Role of estrogens and the molecular underpinnings of aromatase regulation in breast adipose tissue

C Gerard, KA Brown - Molecular and cellular endocrinology, 2018 - Elsevier
One in eight women will develop breast cancer over their lifetime making it the most
common female cancer. The cause of breast cancer is multifactorial and includes hormonal …