Thyroid hormones are crucial for organismal development and homeostasis. In humans,
untreated congenital hypothyroidism due to thyroid agenesis inevitably leads to cretinism …

Identification of the thyroid transcription factors (TTFs), NKX2-1, FOXE1, PAX8 and HHEX,
has considerably advanced our understanding of thyroid development, congenital thyroid …

MAPK signaling inhibitor (MAPKi) therapies show limited efficacy for advanced thyroid
cancers despite constitutive activation of the signaling correlates with disease recurrence …

The primary function of the thyroid gland is to metabolize iodide by synthesizing thyroid
hormones, which are critical regulators of growth, development and metabolism in almost all …

Despite therapeutic advancement, pulmonary disease still remains a major cause of
morbidity and mortality around the world. Opportunities to study human lung disease either …

Current understanding infers a neural crest origin of thyroid C cells, the major source of
calcitonin in mammals and ancestors to neuroendocrine thyroid tumors. The concept is …

Abstract Multipotent Nkx2-1-positive lung epithelial primordial progenitors of the foregut
endoderm are thought to be the developmental precursors to all adult lung epithelial …

The in vitro-directed differentiation of pluripotent stem cells (PSCs) through stimulation of
developmental signaling pathways can generate mature somatic cell types for basic …

Thyroid differentiation of progenitor cells occurs during embryonic development and in the
adult thyroid gland, and the molecular bases of these complex and finely regulated …

The foregut endoderm gives rise to several organs including liver, pancreas, lung and
thyroid with important roles in human physiology. Understanding which genes and …