Olfactory system and energy metabolism: a two-way street

P Jovanovic, CE Riera - Trends in Endocrinology & Metabolism, 2022 - cell.com
Olfactory perception guides daily decisions regarding food consumption, social interactions,
and predator avoidance in all mammalian species. Volatile inputs, comprising odorants and …

GLP-1 suppresses feeding behaviors and modulates neuronal electrophysiological properties in multiple brain regions

XY Chen, L Chen, W Yang, AM Xie - Frontiers in molecular …, 2021 - frontiersin.org
The glucagon-like peptide-1 (GLP-1) plays important roles in the regulation of food intake
and energy metabolism. Peripheral or central GLP-1 suppresses food intake and reduces …

Food odor perception promotes systemic lipid utilization

H Tsuneki, M Sugiyama, T Ito, K Sato, H Matsuda… - Nature …, 2022 - nature.com
Food cues during fasting elicit Pavlovian conditioning to adapt for anticipated food intake.
However, whether the olfactory system is involved in metabolic adaptations remains elusive …

Enzyme-Responsive Modular Peptides Enhance Tumor Penetration of Quantum Dots via Charge Reversal Strategy

Q Dai, Z Du, L Jing, R Zhang… - ACS Applied Materials & …, 2024 - ACS Publications
Quantum dots (QDs) are colloidal semiconductor nanoparticles acting as fluorescent probes
for detection, disease diagnosis, and photothermal and photodynamic therapy. However …

Quercetin modulates expression of serum exosomal long noncoding RNA NEAT1 to regulate the miR-129-5p/BDNF axis and attenuate cognitive impairment in …

H Wang, N Jayasankar, T Thamaraikani, P Viktor… - Life Sciences, 2024 - Elsevier
Aims Cognitive impairment poses a considerable health challenge in the context of type 2
diabetes mellitus (T2DM), emphasizing the need for effective interventions. This study …

Modulating the excitability of olfactory output neurons affects whole-body metabolism

LJ Kolling, R Tatti, T Lowry, AM Loeven… - Journal of …, 2022 - Soc Neuroscience
Metabolic state can alter olfactory sensitivity, but it is unknown whether the activity of the
olfactory bulb (OB) may fine tune metabolic homeostasis. Our objective was to use CRISPR …

Obesity‐and diet‐induced plasticity in systems that control eating and energy balance

CR Ferrario, H Münzberg‐Gruening, L Rinaman… - …, 2024 - Wiley Online Library
Abstract In April 2023, the National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK), in partnership with the National Institute of Child Health and Human Development …

Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice

BM Chelette, AM Loeven, DN Gatlin… - The Journal of …, 2022 - Wiley Online Library
Excess nutrition causes loss of olfactory sensory neurons (OSNs) and reduces odour
discrimination and odour perception in mice. To separate diet‐induced obesity from the …

Optimization of Pichia pastoris Expression System for High-Level Production of Margatoxin

MU Naseem, G Tajti, A Gaspar, TG Szanto… - Frontiers in …, 2021 - frontiersin.org
Margatoxin (MgTx) is a high-affinity blocker of voltage-gated potassium (Kv) channels. It
inhibits Kv1. 1–Kv1. 3 ion channels in picomolar concentrations. This toxin is widely used to …

[HTML][HTML] Exendin-4 increases the firing activity of hippocampal CA1 neurons through TRPC4/5 channels

HZ Sun, FS Shen, XX Li, C Liu, Y Xue, XH Han… - Neuroscience …, 2024 - Elsevier
The central neuropeptide GLP-1 is synthesized by preproglucagon (PPG) neurons in the
brain. GLP-1 receptors are widely distributed in central nervous system. Hippocampus is a …